Elsevier

Immunology Letters

Volume 19, Issue 2, October 1988, Pages 163-167
Immunology Letters

Iron exerts a specific inhibitory effect on CD2 expression of human PBL

https://doi.org/10.1016/0165-2478(88)90137-XGet rights and content

Abstract

The effect of in vitro exposure to ferric citrate (Fecitrate) on the expression of human lymphocyte surface markers was studied. The following markers were examined: E-rosette formation, CD2, CD3, CD4, CD8, CD1, CD22, CD10 and HLA-DR. Pretreatment of peripheral blood lymphocytes (PBL) with Fe-citrate at concentrations ranging from 10−2 M to 10−5 M resulted in the exclusive inhibition of E-rosette formation and CD2 expression. None of the other surface antigens examined appeared to be sensitive to the Fe-citrate treatment. Competition experiments further indicated that iron interacts specifically with CD2 on T lymphocytes.

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