Preliminary evidence for inhibitory effect of glycyrrhizin on HIV replication in patients with AIDS
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Potential of glycyrrhizic and glycyrrhetinic acids against influenza type A and B viruses: A perspective to develop new anti-influenza compounds and drug delivery systems
2023, European Journal of Medicinal ChemistryCitation Excerpt :Antiviral properties of licorice extract may be an important clue in the search for new effective chemical compounds to fight seasonal viral infections. Studies carried out so far have shown that active substances present in the licorice root extract, mainly GA, fought or limited DNA viruses, e.g., human gammaherpesvirus 8, herpes simplex virus, Epstein-Barr virus, hepatitis B virus [27] and RNA viruses, e.g., hepatitis C virus [28,29], coxsackievirus A16, enterovirus 71 [30] or human immunodeficiency virus [31] in vitro. In other in vitro studies, GA was also effective against some RNA viruses attacking cells of the human respiratory tract, such as influenza A virus (H5N1) [27], respiratory syncytial virus [32] or severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) [33] and SARS-CoV-2 [34,35].
Glycyrrhizin: An alternative drug for the treatment of COVID-19 infection and the associated respiratory syndrome?
2020, Pharmacology and TherapeuticsLipids in infectious diseases – The case of AIDS and tuberculosis
2017, Biochimica et Biophysica Acta - BiomembranesCitation Excerpt :Some microdomains act as entry doors, regrouping the molecules required for binding and fusion (i.e. receptors, co-receptors, cholesterol, sphingolipids). Since a long time it has been proposed that a molecule that can change membrane fluidity and organization would present a broad anti-viral activities against enveloped viruses [80–82]. In other words, the disruption of these microdomains or the modulation of their composition might impair virus entry.
Characterization of the interaction of glycyrrhizin and glycyrrhetinic acid with bovine serum albumin by spectrophotometric-gradient flow injection titration technique and molecular modeling simulations
2017, International Journal of Biological MacromoleculesCitation Excerpt :GL (3- O-(2-O-ß-d-glucopyranuronosyl- α-d-glucopyranuronosyl)-18ß-glycyrrhetinic acid) is hydrolyzed to 18ß- glycyrrhetinic acid (3ß -hydroxy-11-oxo-18ß, 20ß -olean-12-en-29-oic acid) in vivo, which is responsible for most of its pharmacological properties. GL has been shown to inhibit growth and cytopathology of numerous RNA and DNA viruses including hepatitis A, B and C (HAV, HBV, and HCV) viruses [45–50], herpes zoster [51], human immunodeficiency virus (HIV) [52–54], herpes simplex [55,56] and human cytomegalovirus (HCMV) [57,58]. It inhibits cell proliferation of prostate cancer in a time and dose-dependent manner [59].
Botanical Ingredients
2017, Cosmetic Science and Technology: Theoretical Principles and ApplicationsSupercritical carbon dioxide extraction of glycyrrhizic acid from licorice plant root using binary entrainer: Experimental optimization via response surface methodology
2015, Journal of Supercritical FluidsCitation Excerpt :GA has anti-inflammatory, anti-ulcer, anti-oxidant, anti-hepatotoxic and anti-virus activities [23–26]. There have been reports that GA has cancer chemo protective function [27] and that it has been used clinically in patient with acids [28]. GA is also used as an additive in some foods and toothpaste.