Elsevier

Antiviral Research

Volume 11, Issues 5–6, June–July 1989, Pages 255-261
Antiviral Research

Preliminary evidence for inhibitory effect of glycyrrhizin on HIV replication in patients with AIDS

https://doi.org/10.1016/0166-3542(89)90035-1Get rights and content

Abstract

Glycyrrhizin (GL) at a dose of 400–1600 mg/day (7.2–30.8 mg/kg/day) was administered intravenously for a period of more than a month, on 6 separate occasions, to 3 hemophiliacs with acquired immune deficiency syndrome (AIDS). Human immunodeficiency virus type 1 (HIV-1) p24 antigen was detected at the beginning of 5 of the 6 treatment courses. Viral antigen was not detected at the end of or during 3 of the 5 treatment courses and decreased to a low level following the 2 other courses. These findings suggest that GL might inhibit HIV-1 replication in vivo.

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