Research reportThe effect of neonatal exposure to chronic footshock on pain-responsiveness and sensitivity to morphine after maturation in the rat
References (28)
- et al.
Opiate receptor ontogeny and morphine-induced effects: influence of chronic footshock stress in prewealing rats
Dev. Brain Res.
(1981) - et al.
Stress-induced analgesia: neural and hormonal determinants
Neurosci. Biobehav. Rev.
(1980) - et al.
Dose-dependent reduction by naloxone of analgesia induced by cold-water stress
Pharmacol. Biochem. Behav.
(1978) Autoanalgesia: opiate and non-opiate mechanism
Neurosci. Biobehav. Rev.
(1980)- et al.
Conditioned fear-induced antinociception and decreased binding of [3H]-N-Leu-enkephalin to rat brain
Brain Res.
(1978) - et al.
The correlation between swim-stress induced antinociception and [3H]Leu-enkephalin binding to brain homogenates in mice
Pharmacol. Biochem. Behav.
(1981) - et al.
Ontological development of opiate receptors in rodent brain
Brain Res.
(1976) - et al.
Ontogenic development of [3H]naloxone binding in rat brain
Neuropharmacology
(1976) - et al.
Analgesic and opioid involvement in the shock-elicited activity and escape deficits produced by inescapable shock
Learn. Motiv.
(1983) - et al.
Effects of heat-stress on behavior and pituitary adrenal axis in rats
Pharmacol. Biochem. Behav.
(1983)
Nociception in mice after chronic stress and chronic narcotic antagonists during maturation
Brain Res.
Protein measurement with the Folin phenol reagent
J. Biol. Chem.
Prolonged intermittent footshock stress decreases Met- and Leu-enkephalin levels in brain with concomitant decreases in pain threshold
Life Sci.
Ontogenesis of enkephalinergic systems in rat brain: postnatal changes in enkephalin levels, receptors and degrading enzyme activities
Life Sci.
Cited by (28)
Early maternal separation and responsiveness to thermal nociception in rodent offspring: A meta-analytic review
2016, Behavioural Brain ResearchCitation Excerpt :For the third methodological influence, separated offspring receiving saline injections had significantly longer RLs than controls while no differences were observed in studies that did not include such injections in separated groups. Possibly, repeated separations accompanied by daily saline injections produced subtle physiological alterations in these samples that ultimately increased nociceptive thresholds during nociceptive testing at 25–45 days of age [28,49]. Specifically, injections during exposure may have resulted, ultimately, in opioid system hyper-responsiveness, although research is needed to determine whether this effect is influenced by differential maternal care following handling episodes featuring injections versus handling alone.
The long-term impact of early life pain on adult responses to anxiety and stress: Historical perspectives and empirical evidence
2016, Experimental NeurologyCitation Excerpt :Animal models of early life pain support clinical findings demonstrating a long-term impact on subsequent responses to pain and stress (Schwaller and Fitzgerald, 2014). Acute or repeated exposure to early life pain induced by foot shock, surgery, or inflammatory agents results in general thermal or mechanical hypoalgesia (i.e., decreased pain sensitivity) in adult rodents (Bhutta et al., 2001; LaPrairie and Murphy, 2007, 2009; Shimada et al., 1990; Sternberg et al., 2005). Consistent with clinical findings showing blunted stress hormones in former preterm infants, early life inflammatory pain in male rats reduces adult release of the stress hormones corticotrophin releasing factor (CRF), arginine vasopressin (VAS), and adrenocorticotrophin releasing hormone (ACTH) following acute swim stress (Anseloni et al., 2005).
Long-term impact of neonatal injury in male and female rats: Sex differences, mechanisms and clinical implications
2010, Frontiers in NeuroendocrinologyCitation Excerpt :Finally, a persistent neonatal lipopolysaccharide immune challenge produces long-lasting hypersensitivity to mechanical and thermal stimuli in adulthood [32]. In contrast, a generalized decrease in nociceptive sensitivity as a consequence of acute or superficial stimulation such as foot shock and intraplantar formalin injections have been demonstrated [29,105]. Likewise, a long-term global elevation of nociceptive thresholds in response to noxious thermal and mechanical stimulation following short-lasting local neonatal inflammation with intraplantar carrageenan has been reported [97].
Anatomy, Physiology, and Effects of Pain
2008, Anesthesia and Analgesia in Laboratory Animals