Localization of Plasmodium falciparum histidine-rich protein 1 in the erythrocyte skeleton under knobs
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The Plasmodium falciparum exported protein PF3D7_0402000 binds to erythrocyte ankyrin and band 4.1
2017, Molecular and Biochemical ParasitologyA spiral scaffold underlies cytoadherent knobs in Plasmodium falciparum-infected erythrocytes
2016, BloodCitation Excerpt :Erythrocytes infected with KAHRP-negative P falciparum lack knobs and show diminished PfEMP1 presentation and reduced adherence to CD36, ICAM-1, and CSA under flow conditions.18-20 KAHRP is localized with PfEMP1 in knobs,18,21 where it has been shown by immuno-EM to be associated with an electron-dense (as visualized in heavy metal–stained specimens) layer of material under the membrane, as well as in Maurer's clefts.22,23 KAHRP is a 59-72 kDa protein (550-657 amino acid residues depending on the variant) containing an N-terminal signal sequence and a PEXEL (Plasmodium export element) motif that mediate export into the erythrocyte, a 63–amino acid histidine-rich (55%) region, and 2 variable tandem repeat regions.24-26
Heterochromatin protein 1 secures survival and transmission of malaria parasites
2014, Cell Host and MicrobeCitation Excerpt :Note that sexual conversion occurs through an unknown mechanism during the cell cycle prior to gametocyte development and that all daughter parasites released from a committed schizont undergo sexual differentiation (Bruce et al., 1990). To discriminate quantitatively between growth-arrested and sexual forms, we visualized the gametocyte-specific marker Pfs16 (Bruce et al., 1994) and knob-associated histidine-rich protein (KAHRP) (a marker for iRBCs) (Taylor et al., 1987) by indirect IFA. Remarkably, 52.7% (±3.1 SD) of 3D7/HP1OFF parasites expressed Pfs16 in generation 2, compared to only 2.3% (±1.2 SD) of background conversion in the 3D7/HP1ON population (Figure 2B).
Cellular architecture of Plasmodium falciparum-infected erythrocytes
2010, International Journal for ParasitologyThe complex morphology of Maurer's clefts: from discovery to three-dimensional reconstructions
2007, Trends in Parasitology