Short communicationStructure of a Plasmodium falciparum gene that encodes a glutamic acid-rich protein (GARP)
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Cited by (29)
Malaria According to GARP: A New Trail towards Anti-disease Vaccination
2020, Trends in ParasitologyHuman erythrocyte band 3 is a host receptor for Plasmodium falciparum glutamic acid–rich protein
2019, BloodCitation Excerpt :PfGARP was identified as a cDNA clone from the expression library of P falciparum isolate FC27 using sera from subjects living in Papua, New Guinea.19 Although the primary structure of the PfGARP gene predicted a mature protein of ∼77 kDa, the reactive sera from malaria patients failed to detect any endogenous protein for unknown reasons.19 A previous study identified PfGARP in a global gene-disruption strategy designed to find parasite proteins that are required for P falciparum erythrocyte membrane protein 1 trafficking and adhesion properties of iRBCs expressing the var2csa variant of P falciparum erythrocyte membrane protein 1 to chondroitin sulfate A.6 The disruption of the PfGARP gene had no effect on the viability or rigidity of iRBCs.6
Expansion of lysine-rich repeats in Plasmodium proteins generates novel localization sequences that target the periphery of the host erythrocyte
2016, Journal of Biological ChemistryCitation Excerpt :Based on the observation that targeting efficiency is dependent upon repeat length, we present a model in which repeat expansion and contraction can generate novel targeting modules or modulate the targeting efficiency of exported parasite proteins. GARP is an 80-kDa protein encoded by the P. falciparum gene PF3D7_0113000 (54). It contains an N-terminal signal sequence for targeting to the parasite endoplasmic reticulum and a PEXEL/HT motif sequence, RLLNE, enabling the protein to be exported into the host erythrocyte.
Malaria Parasite Proteins and Their Role in Alteration of the Structure and Function of Red Blood Cells
2016, Advances in ParasitologyThe malaria-infected red blood cell: Structural and functional changes
2001, Advances in Parasitology