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Structure of a Plasmodium falciparum gene that encodes a glutamic acid-rich protein (GARP)

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Cited by (29)

  • Human erythrocyte band 3 is a host receptor for Plasmodium falciparum glutamic acid–rich protein

    2019, Blood
    Citation Excerpt :

    PfGARP was identified as a cDNA clone from the expression library of P falciparum isolate FC27 using sera from subjects living in Papua, New Guinea.19 Although the primary structure of the PfGARP gene predicted a mature protein of ∼77 kDa, the reactive sera from malaria patients failed to detect any endogenous protein for unknown reasons.19 A previous study identified PfGARP in a global gene-disruption strategy designed to find parasite proteins that are required for P falciparum erythrocyte membrane protein 1 trafficking and adhesion properties of iRBCs expressing the var2csa variant of P falciparum erythrocyte membrane protein 1 to chondroitin sulfate A.6 The disruption of the PfGARP gene had no effect on the viability or rigidity of iRBCs.6

  • Expansion of lysine-rich repeats in Plasmodium proteins generates novel localization sequences that target the periphery of the host erythrocyte

    2016, Journal of Biological Chemistry
    Citation Excerpt :

    Based on the observation that targeting efficiency is dependent upon repeat length, we present a model in which repeat expansion and contraction can generate novel targeting modules or modulate the targeting efficiency of exported parasite proteins. GARP is an 80-kDa protein encoded by the P. falciparum gene PF3D7_0113000 (54). It contains an N-terminal signal sequence for targeting to the parasite endoplasmic reticulum and a PEXEL/HT motif sequence, RLLNE, enabling the protein to be exported into the host erythrocyte.

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