Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Resular paper1,25-Dihydroxyvitamin D-3 induces arachidonate mobilization in embryonic chick myoblasts
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2013, Ageing Research ReviewsCitation Excerpt :The iPLA2 shows a unique tissue distribution, yet in general terms this enzyme is ubiquitously expressed in a wide variety of cells and tissues, including the rat small intestine (Fukushima and Serrero, 1994). Activation of PLA2 by 1α,25(OH)2D3 was demonstrated in different cell types, such as skeletal muscle cells (Boland et al., 1995), chondrocytes (Schwartz and Boyan, 1988) and hepatocytes (Baran and Kelly, 1988), being dihydropyridine-sensitive extracellular Ca2+ influx required for the modulatory effects of 1α,25(OH)2D3 on PLA2 (Boland and Boland, 1993). In rat duodenal cells, 1α,25(OH)2D3 activates a Ca2+-dependent cytosolic PLA2 and attendant arachidonic acid release and this activation requires prior stimulation of intracellular ERK1/2 (Gentili et al., 2004a).
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