Review
Tickling the TCR: selective T-cell functions stimulated by altered peptide ligands

https://doi.org/10.1016/0167-5699(93)90200-5Get rights and content

Abstract

Recent observations of T-cell responses following T-cell receptor (TCR) interaction with altered peptide ligands have highlighted the complexity of this signalling system. The indications are that the TCR responds to minor changes in ligand with gradations of T-cell activation and effector functions. Brian Evavold, Joanne Sloan-Lancaster and Paul Allen review these studies and present a model in which partial T-cell activation and TCR antagonism are related events in a continuum of signalling through the TCR.

References (60)

  • M.T. De Magistris et al.

    Cell

    (1992)
  • S.M. Hedrick et al.

    Cell

    (1982)
  • J.B. Rothbard et al.

    Cell

    (1988)
  • J. Hammer et al.

    Cell

    (1993)
  • P. Dellabona et al.

    Cell

    (1990)
  • I.R. Cohen

    Immunol. Today

    (1992)
  • C.A. Janeway

    Current Biology

    (1992)
  • R.H. Schwartz

    Cell

    (1992)
  • R.D. Klausner et al.

    Cell

    (1991)
  • A. Weiss

    Cell

    (1993)
  • A-M.K. Wegener et al.

    Cell

    (1992)
  • P. Kourilsky et al.

    Cell

    (1989)
  • H. von Boehmer

    Immunol. Today

    (1992)
  • P.G. Ashton-Rickardt et al.

    Cell

    (1993)
  • B.D. Evavold et al.

    Science

    (1991)
  • B.D. Evavold et al.

    J. Immunol.

    (1993)
  • J. Sloan-Lancaster et al.

    Nature

    (1993)
  • A. Sette et al.

    Nature

    (1987)
  • P.M. Allen et al.

    Nature

    (1987)
  • B.D. Evavold et al.

    J. Immunol.

    (1992)
  • J.L. Jorgensen et al.

    Annu. Rev. Immunol.

    (1992)
  • L. Racioppi et al.

    J. Exp. Med.

    (1993)
  • S.C. Jameson et al.

    J. Exp. Med.

    (1993)
  • D. Ostrov et al.

    J. Immunol.

    (1993)
  • B.P. Babbitt et al.

    Nature

    (1985)
  • S. Buus et al.
  • A.R.M. Townsend et al.

    Nature

    (1986)
  • P.J. Bjorkman et al.

    Nature

    (1987)
  • M.M. Davis et al.

    Nature

    (1988)
  • D.R. Madden et al.

    Nature

    (1991)
  • Cited by (0)

    We would like to thank our Laboratory-staff for their fruitful comments and useful discussion, Drs Abul Abbas, Audrey Shaw, Reobert Schreiber and Emil Unanue for critical review of this manuscript, and Dr Leslie Berg for permission to include her unpublished work.

    View full text