Viewpoint
Practical, biochemical and evolutionary implications of the discovery of HLA class I supermotifs

https://doi.org/10.1016/0167-5699(96)80542-1Get rights and content

Abstract

Recent data suggest that the majority of HLA-A and -B alleles in human populations can be grouped into four major supertypes, as defined by their broad peptide-binding specificities. As discussed by John Sidney and colleagues, these data add to our understanding of the evolutionary and biochemical processes involved in the generation of MHC polymorphism, and suggest that HLA class I alleles may ultimately be reclassified on the basis of their peptide-binding specificities.

References (27)

  • J.C. Howard

    Curr. Opin. Immunol.

    (1995)
  • P.A. Wentworth et al.

    Mol. Immunol.

    (1995)
  • M.A. Saper et al.

    J. Mol. Biol.

    (1991)
  • D.R. Madden et al.

    Cell

    (1993)
  • J. Sidney et al.

    Hum. Immunol.

    (1996)
  • L.D. Barber et al.

    Curr. Biol.

    (1995)
  • N. Tanigaki et al.

    Hum. Immunol.

    (1994)
  • M.A. Fernandez-viña et al.

    Hum. Immunol.

    (1992)
  • S. Itescu et al.

    Hum. Immunol.

    (1995)
  • D.R. Madden

    Annu. Rev. Immunol.

    (1995)
  • R.N. Germain et al.

    Annu. Rev. Immunol.

    (1993)
  • A.V.S. Hill et al.

    Nature

    (1992)
  • A. Vitiello et al.

    J. Clin. Invest.

    (1995)
  • Cited by (0)

    View full text