Nucleotide sequence of the S RNA of Lassa virus (Nigerian strain) and comparative analysis of arenavirus gene products☆
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Cited by (46)
Lassa Fever: A rodent-human interaction
2013, The Role of Animals in Emerging Viral DiseasesYellow fever 17D-vectored vaccines expressing Lassa virus GP1 and GP2 glycoproteins provide protection against fatal disease in guinea pigs
2011, VaccineCitation Excerpt :The L RNA encodes a large protein (L, or RNA-dependent RNA polymerase) [34], and a small zinc-binding Z protein [35]. The S RNA encodes the major structural proteins, nucleoprotein (NP) and glycoprotein precursor (GPC), cleaved into GP1, GP2, and a stable signal peptide, SSP [36–38]. In contrast to YF, CD8+ T cell responses play a major role in protection against LASV.
Safety, immunogenicity, and efficacy of the ML29 reassortant vaccine for Lassa fever in small non-human primates
2008, VaccineCitation Excerpt :The L RNA encodes a large protein (L, or RNA-dependent RNA polymerase) [13], and a small zinc-binding, Z protein [14]. The S RNA encodes the major structural proteins, nucleoprotein (NP), and glycoprotein precursor (GPC), cleaved into GP1, GP2, and signal peptide [15–17]. We previously described a live attenuated experimental vaccine for LF, clone ML29 [18–20].
A ML29 reassortant virus protects guinea pigs against a distantly related Nigerian strain of Lassa virus and can provide sterilizing immunity
2007, VaccineCitation Excerpt :The L RNA encodes a large protein, L, or RNA-dependent RNA polymerase (RdRp) [15], and a small zinc-binding, Z protein [16]. The S RNA encodes the major structural proteins, nucleoprotein (NP) and glycoprotein precursor (GPC), cleaved into GP1 and GP2 [17–19]. The ML29 vaccine candidate encodes the nucleocapsid (NP) and glycoprotein (GPC) of LASV (Josiah/SL/76/H) and the Z protein and RNA polymerase (RdRp) of Mopeia virus (MOPV-AN20410), a non-pathogenic relative of LASV [10–12].
Sequence analysis of L RNA of Lassa virus
2004, VirologyCitation Excerpt :It could be partially overcome by applying specific reaction conditions. As observed for the Lassa virus S RNA (Auperin and McCormick, 1989; Bowen et al., 2000; Clegg et al., 1991; Günther et al., 2000, 2001), the RNA stem-loop structure of the L RNA was completely conserved, suggesting important functions of this structure in the virus life cycle. Looking at the L protein alone, there are some clear results and some totally unresolved questions.
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Sequence data in this paper have been deposited in the EMBL Data Library under accession no. X52400.