Microspheres for targeting drugs to specific body sites
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Cited by (92)
Effect of hydrothermal conditions on production of coal organic microspheres
2018, FuelCitation Excerpt :Organic or carbonaceous microspheres (OM) are spherical particles with diameters from 1 μm to 1000 μm, mostly consisting of organic compositions. OM have significant applications in drug delivery systems, such as targeted drug delivery [1–3], controlled and sustained drug delivery [4–6], and in the field of functional materials. OM are the resources of hard carbon microspheres [7,8], mesoporous OM used for catalytic reactions [9], and the hybrid carbon/inorganic materials with core-shell structure [10,11], and OM have also been used as a template for synthesizing various hollow metal oxide microspheres [12–14].
Evaluation of the versatile character of a nanoemulsion formulation
2016, International Journal of PharmaceuticsCitation Excerpt :To be administrable by the i.v. route, preparations should present preferred physico-chemical properties, i.e. to be buffered at pH 7.4, to be isotonic to plasma, and to be sterile. Moreover, the nanodroplets should ideally be monodisperse in size, and smaller than ∼200 nm for an optimal delivery to the systemic circulation (Davis et al., 1993). Considering that the hydrodynamic size of the nanodroplets is directly correlated with the surfactant/oil weight ratio (SOR) (Hallouard et al., 2013), and as our preliminary assays have permitted to obtain nanodroplets with an acceptable hydrodynamic diameter, we further investigated the influence of the composition of the nanoemulsion on its granulometric properties by varying the surfactant-oil/water weight ratio (SOWR) while keeping the SOR unchanged (SOR = 80%).
Multifunctional nanocarriers
2012, Advanced Drug Delivery ReviewsCitation Excerpt :For some diagnostic applications the administration of diagnostic particulates of a significantly smaller size is required. One of such situations arises, for example, during percutaneous lymphography, as it has been shown with polystyrene nanospheres that particulate uptake in the primary lymph node after subcutaneous injection is drastically increased with decreasing particle size especially when nanospheres with a diameter below 100 nm were used [238]. To still further increase liposome load with diagnostic moieties, amphiphilic polychelating polymers (PAP) were synthesized consisting of the main chain with multiple side chelating groups capable of firm binding many reporter metal atoms and hydrophobic terminal group allowing for polymer adsorption onto hydrophobic nanoparticles or incorporation into hydrophobic domains of liposomes or micelles [239].
Iodinated blood pool contrast media for preclinical X-ray imaging applications - A review
2010, BiomaterialsCitation Excerpt :The particle size entrapping the contrast agent is also an important parameter influencing the long-circulating properties. In order to reside in the blood pool for a long time, their size must be larger than 10 nm which corresponds to the width of fenestrated capillaries [38], but must be small enough (generally below 200 nm) as the RES uptake rate increases according to their size. Numerous experimental and clinical reports have confirmed a passive accumulation of intravenously injected long-circulating particles in solid tumors [39–48].
Multifunctional nanocarriers
2006, Advanced Drug Delivery ReviewsPreparation, characterization and in vitro drug release studies of novel polymeric nanoparticles
2006, International Journal of Pharmaceutics