Selenium in chronic liver disease

doi:10.1016/0168-8278(92)90155-I

Journal of Hepatology

Volume 14, Issues 2–3, March 1992, Pages 176-182

https://doi.org/10.1016/0168-8278(92)90155-I Get rights and content

Abstract

In order to assess the role of selenium (Se) in chronic liver disease, we have measured serum, urinary and hepatic selenium in a range of liver diseases and correlated them with nutritional status and conventional liver biochemistry. Serum Se levels (μg/l ± S.D.) were significantly lower in both alcoholic (63.6 ± 18.2, p < 0.0001) and non-alcoholic liver disease (NALD) (60.6 ± 13.6, p < 0.0001) compared to healthy controls (87.8 ± 21.2) and non-malignant ‘disease controls’ (80.3 ± 19.1). Hepatic Se levels (μg/g of dry weight) were also reduced in both ALD (0.568 ± 0.647, p < 0.005) and NALD (0.863 ± 0.308, p < 0.005) compared to controls (1.227 ± 0.296), 24-h urinary Se excretion (μg) in ALD (24.6 ± 10.7) and NALD (29.0 ± 14.3) was similar to controls (30.3 ± 8.7). Serum Se showed a highly significant positive correlation with albumin (p < 0.001) in both ALD and NALD. Serum levels were also significantly correlated with anthropometric measurements. Dietary assessment of patients with primary biliary cirrhosis and low serum Se levels did not show a reduced dietary intake. Our data show that Se levels are low in liver disease irrespective of aetiology and suggest that these low levels are more likely to be related to overall nutritional status than to dietary intake.

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Regular paperSelenium in chronic liver disease

Abstract

Lancet

Clin Chim Acta

Am J Clin Nutr

Am J Clin Nutr

Lancet

Am J Clin Nutr

Am J Clin Nutr

Clin Chim Acta

J Chronic Dis

Clin Chim Acta

Biochim Biophys Acta

Clin Chim Acta

Lancet

Selenium as an integral part of factor 3 against dieatry necrotic liver degeneration

J Am Chem Soc

Selenium: biochemical role as a component of glutathione peroxidase

Science

Glutathione peroxidase

Association between serum selenium and the risk of cancer

Am J Epidemiol

Risk of cancer in relation to serum concentrations of selenium and vitamin A and E: matched case-control analysis of prospective data

Br Med J

Anti-oxidants and cancer 1. Selenium in the blood of normals and cancer patients

J. Natl Cancer Inst

The relationship of dietary selenium and breast cancer

J Surg Oncol

Regular paper
Selenium in chronic liver disease