Trends in Genetics
Volume 12, Issue 8, August 1996, Pages 306-310
Journal home page for Trends in Genetics

Review
Flies on steroids — Drosophila metamorphosis and the mechanisms of steroid hormone action

https://doi.org/10.1016/0168-9525(96)10032-9Get rights and content

Abstract

Recent studies have provided new insights into the molecular mechanisms by which the steroid hormone ecdysone triggers the larval-to-adult metamoprhosis of Drosophila. Ecdysome-induced transcription factors activate large sets of secondary-response genes and provide the competence for subsequent regulatory responses to the hormone. It seems likely that similar hormone-triggered regulatory hierarchies exist in other higher organisms and that Drosophila is providing our first glimpses of the complexities of these gene networks.

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