Review
Metronidazole and drug resistance

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Abstract

In recent years, the basis of metronidozole resistance has been examined in anaerobic protozoa, such as Trichomonas and Giardia, as well as anaerobic bacteria, such as Bacteroides and Clostridium. In this review, Patricia Johnson looks at a variety of mechanisms that lead to reduced susceptibility of these pathogens to the drug. The frequent correlation between metronidozole resistance and inefficient drug activation suggests that this is the level at which drug resistance operates.

References (50)

  • R.M.J. Ings et al.

    Biochem. Pharmacol.

    (1974)
  • M. Muller

    Biochem. Pharmacol.

    (1986)
  • N. Yarlett

    Mol. Biochem. Parasitol.

    (1985)
  • A. Cerkasovova et al.

    Mol. Biochem. Parasitol.

    (1984)
  • N. Yarlett et al.

    Biochem. Pharmacol.

    (1986)
  • D. Lloyd et al.

    Biochem. Pharmacol.

    (1986)
  • D.L. Church et al.

    Biochem. Pharmacol.

    (1988)
  • E. Knight et al.

    J. Biol. Chem.

    (1967)
  • S.N.J. Moreno

    J. Biol. Chem.

    (1983)
  • S.N.J. Moreno et al.

    J. Biol, Chem.

    (1984)
  • J. Breuil

    Plasmid

    (1989)
  • G.U. Wehnert

    Plasmid

    (1990)
  • N.C. Smith et al.

    Internatl J. Parasitol.

    (1988)
  • N. Yarlett et al.

    Mol. Biochem. Parasitol.

    (1986)
  • S.J. Foote

    Cell

    (1989)
  • H.L. Callahan et al.

    J. Biol. Chem.

    (1991)
  • J. Samuelson

    Mol. Biochem. Parasitol.

    (1990)
  • A.M. van der Bliek et al.

    Adv. Cancer Res.

    (1989)
  • M. Muller

    Surgery

    (1983)
  • V.L. Sutter
  • M. Sebald et al.
  • A.C. Begg et al.

    Br. J. Radial.

    (1974)
  • J. Denekamp et al.

    Radiat. Res.

    (1974)
  • J.W. Smith et al.

    Annu. Rev. Med.

    (1980)
  • C.M. Beard

    N. Engl. J. Med.

    (1979)
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