International Journal of Immunopharmacology
Inhibitory effects of FUT-175, a new synthetic protease inhibitor, on intravascular hemolysis by human serum in mice
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2020, Blood AdvancesCitation Excerpt :In these mice, after NHS injection, mouse intravascular hemolysis mediated by activated human complement can be easily quantitated by measuring released hemoglobin in the plasma. Using this model, we and others demonstrated previously that complement inhibitors such as FUT-17513 and SSL-736 significantly reduced intravascular hemolysis, a common feature in patients with PNH, cold agglutinin disease, and aHUS. We found that when blood was collected 10 minutes after NHS injection to measure intravascular hemolysis, it showed that 1C9 administration significantly prevented or even abolished the human complement–mediated RBC destruction.
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