Issues in the mortality analysis of randomized controlled trials of cancer screening
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Cited by (27)
Computed Tomography Screening: The International Early Lung Cancer Action Program Experience
2015, Thoracic Surgery ClinicsCitation Excerpt :They do this by choosing a cutoff for the difference in the mortality rates that is considered to be clinically important (eg, 20% in the NLST). This difference influences the study design as to the number of participants, how many rounds of screening, and length of follow-up that need to be provided.52 All of these design parameters (significant mortality reduction, number of years of screening, and follow-up) must be determined in advance of the actual trial.
Assessment of lung-cancer mortality reduction from CT Screening
2011, Lung CancerCitation Excerpt :Once screening stops, lung-cancer deaths are expected to increase and will ultimately reach the same rate as in the absence of screening. Randomized controlled screening trials which typically provide a limited number of rounds of screening are not immune to these concerns [24–27]. This report is the first known report on lung cancer mortality based on a age-, sex-, and smoking history-adjusted approach comparing screening with two unscreened cohorts.
Estimating the difference in location parameters of two survival curves, with applications to cancer screening
1997, Journal of Statistical Planning and InferenceEpidemiologic Methods: The Essentials
2022, Epidemiologic Methods: The EssentialsScreening Theory and Study Design: The Basics
2021, Cancer Screening: Theory and PracticeThe importance of the regimen of screening in maximizing the benefit and minimizing the harms
2016, Annals of Translational Medicine