Acetyl-l-carnitine: Behavioral, electrophysiological, and neurochemical effects
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Reelin changes hippocampal learning in aging and Alzheimer's disease
2021, Behavioural Brain ResearchCitation Excerpt :Furthermore, Reelin deficiencies have been correlated to higher clinical dementia rating in AD patients [22] and cognitive decline in rats [23]. Given the localization of these Reelin expressing neurons and their implication in AD, we sought to investigate whether Reelin deficiency in adult mice in conjunction with known AD risk-factors produced a behavioral phenotype using the HF-dependent tasks trace fear conditioning (TFC) and the Barnes maze (BM) [24–28]. While aged rodents have a well-documented association with spatial memory impairments [25,26,28–31], the conjoined effect of Reelin deficiency and age has not been well characterized.
Memory in aged mice is rescued by enhanced expression of the GluN2B subunit of the NMDA receptor
2013, Behavioural Brain ResearchCitation Excerpt :Similar results were also observed in other species, including rats [11,44,72], canids [65], non-human primates [66] and humans [73]. Several studies have used spatial memory tasks to characterize the relationship between age-related declines in memory and NMDA receptor expression [8–12,61,62,67,74–78]. Specifically, the age-related decline in densities of NMDA receptor binding and expression of its subunits in regions of the frontal lobe and hippocampus of the rodent brain have been shown to be associated with declines in spatial memory, including spatial long-term and delayed short-term memory, during aging [8–12,44,61,62,67,78].
Aging impairs hippocampus-dependent long-term memory for object location in mice
2012, Neurobiology of AgingLipid changes in the aged brain: Effect on synaptic function and neuronal survival
2012, Progress in Lipid ResearchThe N-methyl-d-aspartate receptor modulator GLYX-13 enhances learning and memory, in young adult and learning impaired aging rats
2011, Neurobiology of AgingCitation Excerpt :Cognitive deficits in aging correlate with NMDAR deficits. Protein levels of NR1 (Adams et al., 2001) and NMDAR binding (Davis et al., 1993) in rats both correlate positively with learning acquisition rates in the MWM. Moreover, old rats are more sensitive than young adult rats to the memory impairing effect of the NMDA open channel blocker MK-801 (Ingram et al., 1992).