Immune suppression gene on HLA-Bw54-DR4-DRw53 haplotype controls nonresponsiveness in humans to hepatitis B surface antigen via CD8+ suppressor T cells
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Vaccinomics: A scoping review
2023, VaccineThe role of human leukocyte antigen tissue groups inhepatitis B virus vaccination in Turkey
2014, Journal of Microbiology, Immunology and InfectionCitation Excerpt :Another report has shown that nonresponsiveness to the hepatitis B vaccine is strongly associated with the extended HLA haplotype B44; DRB1*0701, DQB1*0202 genotype.12 In Japanese individuals, the Bw54-DR4-DQW4 haplotype has been connected with poor vaccine responses.13–15 Nevertheless, most studies regarded a limited number of alleles and nonresponders, meaning that the results were rarely statistically significant.
Genetic variants within the MHC region are associated with immune responsiveness to childhood vaccinations
2013, VaccineCitation Excerpt :The contribution of the MHC variants to the vaccine immune response was first observed by a significant excess of HLA-DR7 and a total absence of HLA-DR1 in individuals that failed to respond to hepatitis B vaccine [14]. Subsequent studies revealed associations between certain HLA class II (HLA-DR, HLA-DQ) alleles and poor or non-immune response to HBV [6,9,15–19]. In addition, poor responsiveness to hepatitis B vaccine was associated with extended MHC haplotypes such as B8-DR3-SC01, B44-DR7-FC31 and B18-DRB1*0301-DQB1*0201 [6,15,18–20].
Induction of anti-HBs in HB vaccine nonresponders in vivo by hepatitis B surface antigen-pulsed blood dendritic cells>
2007, Journal of HepatologyCitation Excerpt :Moreover, the levels of antibody to HBsAg (anti-HBs) of an unknown further fraction of hepatitis B (HB) vaccinated persons fall considerably over time rendering them at potential risk of infection. The exact mechanisms underlying non responsiveness to HB vaccine are not known, however, certain human leukocyte antigen (HLA) and murine major histocompatibility complex haplotypes are related with HB vaccine non-responsiveness [4–7]. In addition, investigators have shown that immune responses to HBsAg are not properly induced in HB vaccine nonresponders due to inadequate priming of T and B lymphocytes [8,9].
Human Papillomavirus Infection in Men and Women: The Impact of Nutrition on Cervical Cancer
2004, Principles of Gender-Specific MedicineImmunogenetics of the response to HBsAg vaccination
2003, Autoimmunity Reviews