Elsevier

Human Immunology

Volume 35, Issue 1, September 1992, Pages 29-39
Human Immunology

Evolutionary stability of transspecies major histocompatibility complex class II DRB lineages in humans and rhesus monkeys

https://doi.org/10.1016/0198-8859(92)90092-2Get rights and content

Abstract

Sequence analysis of rhesus monkey (Macaca mulatta) polymorphic second exon of major histocompatibility complex class II DRB subregion genes demonstrates the existence of at least 34 alleles. Some of these rhesus monkey alleles are very similar (or nearly identical) to HLA-DRB alleles. These data demonstrate that members of the lineages for Mhc-DRB103, -DRB104, -DRB110, and the loci of Mhc-DRB3, -DRB4, -DRB5, and -DRB6 predate speciation of man and rhesus monkey and were already present 25 million years ago. Calculation of evolutionary rates suggests that the various allele lineages have differential stabilities. Furthermore, the data indicate that distinct species may not have inherited or lost transspecies Mhc-DRB lineages in evolution, because several allele lineages in rhesus monkeys appear to be absent in humans and vice versa.

References (41)

  • J.H. Roger et al.

    The major histocompatibility complex of rhesus monkeys. 13. Current knowledge of DR and other B-cell specific antigens

    J Immunogenet

    (1980)
  • M. Jonker et al.

    Typing for RhLA-D in rhesus monkeys. 2. Genetics of the D antigens and their associations with DR antigens in a population of unrelated animals

    Tissue Antigens

    (1982)
  • P. Parham et al.

    Diversity and diversification of HLA-A,B,C alleles

    J Immunol

    (1989)
  • W.E. Mayer et al.

    Nucleotide sequences of chimpanzee MHC class I alleles: evidence for trans-species mode of evolution

    EMBO J

    (1988)
  • D.I. Watkins et al.

    Evolution of the MHC class I genes of a New World primate from ancestral homologues of human non-classical genes

    Nature

    (1990)
  • U. Gyllensten et al.

    Genetic diversity at class II DRB loci of the primate MHC

    J Immunol

    (1991)
  • D.A. Lawlor et al.

    HLA-A and B polymorphisms predate the divergence of humans and chimpanzees

    Nature

    (1988)
  • D.A. Lawlor et al.

    Comparison of class I MHC alleles in humans and apes

    Immunol Rev

    (1990)
  • M. Kasahara et al.

    Evolution of the class II major histocompatibility complex in higher primates

    Immunol Rev

    (1990)
  • R.van Lambalgen et al.

    Experimental allergic encephalomyelitis in rhesus monkeys. 1. Immunological parameters in EAE resistant and susceptible rhesus monkeys

    Clin Exp Immunol

    (1987)
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