PaperConstruction and immunogenicity of Salmonella typhimurium vaccine vectors that express HIV-1 gp120
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Cited by (36)
Vaccines for Human Immunodeficiency Virus Type 1 Infection
2014, Mandell, Douglas, and Bennett's Principles and Practice of Infectious DiseasesImmune response and protective efficacy of live attenuated Salmonella vaccine expressing antigens of Mycobacterium avium subsp. paratuberculosis against challenge in mice
2012, VaccineCitation Excerpt :Attenuated derivatives of Salmonella enterica have been used as a delivery system for heterologous antigens to induce protective immunity against several infectious diseases in model animals [12–14]. Vaccination with live attenuated Salmonella expressing various heterologous antigens (HIV Gag, gp120 and Ag85A) not only resulted in the generation of strong TH1 biased systemic immune response [15–19] but also augmented mucosal immunity [18]. However, the potential of attenuated Salmonella expressing protective MAP antigens as a vaccine candidate against MAP infection has not been evaluated to date.
Immunologic basis of vaccine vectors
2010, ImmunityCitation Excerpt :Several attributes of bacteria led to their development as vaccine vectors. These included the ability to deliver them via the oral route, which is the natural route of infection for a variety of bacteria such as Salmonella (Fouts et al., 1995a; Fouts et al., 1995b), (Chin'ombe et al., 2009), (Huang et al., 2009), Shigella (Fennelly et al., 1999), and certain Mycobacteria such as M. bovis (Ferrari et al., 2000). Of note, attenuated bacteria are used.
Human immunodeficiency virus vaccines
2008, VaccinesIn vitro and in vivo stability of recombinant plasmids in a vaccine strain of Salmonella enterica var. Typhimurium
2003, FEMS Immunology and Medical MicrobiologySalmonella vaccines for use in humans: Present and future perspectives
2002, FEMS Microbiology ReviewsCitation Excerpt :In other studies, it was found that the gp120 antigen of human immunodeficiency virus-1 formed inclusion bodies when expressed in the Salmonella cytosol, but could be produced in a soluble form when the antigen was secreted [81,119].