Paper
Resistance modification by PSC-833, a novel non-immunosuppressive cyclosporin A

https://doi.org/10.1016/0277-5379(91)90435-GGet rights and content

Abstract

A novel non-immunosuppressive cyclosporin A, PSC-833, has been tested for its ability to circumvent resistance to doxorubicin, vincristine and colchicine in human and murine multidrug resistantant (MDR) cell lines. This compound is shown to be a highly potent resistance modifier, being 7–10-fold more potent than the parent compound, cyclosporin A, whilst approximately equal to cyclosporin A in the growth inhibitory effects of compound alone. Reversal of the P-glycoprotein-associated MDR drug accumulation defect is a major component of resistance reversal for PSC-833, as it is for cyclosporin A.

References (21)

  • T Mosmann

    Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays

    J Immunol Meth

    (1983)
  • D Boesch et al.

    Restoration of daunomycin retention in multidrug resistant P388 cells by submicromolar concentrations of SDZ PSC 833, a nonimmunosuppressive cyclosporin derivative

    Exp Cell Res

    (1991)
  • WS Dalton et al.

    Drug resistance in multiple myeloma and non-Hodgkin's lymphoma: detection of P-glycoprotein and potential circumvention by addition of verapamil to chemotherapy

    J Clin Oncol

    (1989)
  • TP Miller et al.

    P-glycoprotein expression in malignant lymphoma and reversal of clinical drug resistance with chemotherapy plus high-dose verapamil

    J Clin Oncol

    (1991)
  • RD Jones et al.

    A pilot study of quinidine and epirubicin in the treatment of advanced breast cancer

    Br J Cancer

    (1990)
  • P Sonneveld et al.

    Reversal of drug-resistance by cyclosporin-A in a patient with acute myelocytic leukaemia

    Br J Haematol

    (1990)
  • LM Slater et al.

    Cyclosporin A reverses vincristine and daunorubicin resistance in acute lymphocytic leukaemia in vitro

    J Clin Invest

    (1986)
  • M Naito et al.

    Competitive inhibition by verapamil for ATP-dependent high affinity vincristine binding to the plasma membrane of multidrug resistance K562 cells without calcium ion involvement

    Cancer Res

    (1989)
  • PR Twentyman et al.

    Cyclosporin A and its analogues as modifiers of adriamycin and vincristine resistance in a multidrug resistant human lung cancer cell line

    Br J Cancer

    (1987)
  • PR Twentyman

    Modification of cytotoxic drug resistance by non-immunosuppressive cyclosporins

    Br J Cancer

    (1988)
There are more references available in the full text version of this article.

Cited by (0)

View full text