Agglutinating activity of wheat gliadin peptide fractions in coeliac disease
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Cited by (23)
Next-generation therapies for celiac disease: The gluten-targeted approaches
2018, Trends in Food Science and TechnologyCitation Excerpt :Beyond gluten-targeted therapies, others were developed aiming to manage the known mechanisms of mucosal damage in celiac disease. For example, decreasing intestinal permeability (Kelly et al., 2009; Paterson, Lammers, Arrieta, Fasano, & Meddings, 2007), inhibitors of TG2 activity (Choi et al., 2005; de Macédo, Marrano, & Keillor, 2002; Hausch, Halttunen, Mäki, & Khosla, 2003; Jeitner, Delikatny, Ahlqvist, Capper, & Cooper, 2005; Lai, Slaughter, Peoples, Hettasch, & Greenberg, 1998; Maiuri et al., 2005; Molberg et al., 2001; Pardin, Roy, Lubell, & Keillor, 2008), inhibition of gluten peptide presentation by HLA-DQ2 antagonists (Anderson, van Heel, Tye-Din, Jewell, & Hill, 2006; Bolin et al., 2000; Falcioni et al., 1999; Kapoerchan et al., 2008; Xia et al., 2007; Xia, Siegel, Bergseng, Sollid, & Khosla, 2006), gluten peptides that down-regulate the innate immune response (De Vincenzi, Dessi, Giovannini, Maialetti, & Mancini, 1995; De Vincenzi, Gasbarrini, & Silano, 1997; Silano et al., 2008; Silano, Di Benedetto, et al., 2007; Silano, Leonardi, et al., 2007) and immune modulation and induction of tolerance to gluten (Croese et al., 2015; Huibregtse et al., 2009; Keech, Dromey, Chen, Anderson, & McCluskey, 2009; Maurano et al., 2001; Medina, De Palma, Ribes-Koninckx, Calabuig, & Sanz, 2008; Rossi et al., 1999; Senger et al., 2003) were described. Additional therapies currently used or evaluated for other autoimmune diseases, such as rheumatoid arthritis and/or inflammatory bowel disease, are being studied for possible application in the treatment of refractory celiac disease (a condition very similar to celiac disease, but which cannot be relieved before at least 12 months of the gluten-free diet) and enteropathy-associated T-cell lymphoma (Schuppan, Junker, & Barisani, 2009).
Celiac Disease: From Pathogenesis to Novel Therapies
2009, GastroenterologyCitation Excerpt :Of note, transglutaminase inhibitors based on a high affinity thiol binding group were recently developed that display 70- to 225-fold specificity for TG2 over TG1, TG3, TG6, and factor XIII when tested in vitro (Pasternack R, Hils M, Zedira Company, Darmstadt, Germany, personal communication, September 2009), raising hopes for increased safety of this approach. An “innate inhibitory” decapeptide (sequence QQPQDAVQPF) was isolated by affinity chromatography and gel filtration from durum wheat and tested in various in vitro systems.242–249 This peptide prevented agglutination of K562 erythroleukemic cells induced by PT-digested gliadin or α-gliadin p31-43243,245 and protected Caco2 intestinal epithelial cells from apoptosis induced by gliadin.246
Protective effects of mannan in Caco-2/TC7 cells treated with wheat-derived peptides
2005, Carbohydrate PolymersGliadin cytotoxicity and in vitro cell cultures
2003, Toxicology LettersIn vitro cytotoxic effect of wheat gliadin-derived peptides on the Caco-2 intestinal cell line is associated with intracellular oxidative imbalance: Implications for coeliac disease
1999, Biochimica et Biophysica Acta - Molecular Basis of Disease