Inhibitory effects of ursolic and oleanolic ancid on skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate

doi:10.1016/0304-3835(86)90067-4

Cancer Letters

Volume 33, Issue 3, December 1986, Pages 279-285

https://doi.org/10.1016/0304-3835(86)90067-4 Get rights and content

Abstract

Ursolic acid (UA) and oleanolic acid (OA), which had been isolated from Glechoma hederacea as inhibitors of Epstein-Barr virus (EBV) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), were tested against inhibitory effect on tumor promotion by TPA in vivo. They inhibited effectively the tumor promotion in mouse skin and the activities were comparable to that of a known inhibitor of tumor promotion, retinoic acid (RA). Interestingly, UA was more effective on a single application before initial TAP-treatment than on a continuous application before each TPA-treatment, while OA and RA were ineffective in the same treatment. These data suggest that the role of UA for inhibitory action on tumor promotion differs slightly from those of RA and OA.

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Cancer Letters

Abstract

References (17)

Combined effect of the extracts from Croton tiglium, Euphorbia lathyris, or Euphorbia tirucalli and n-butyrate on Epstein-Barr virus expression in human lymphoblastoid P3HR-1 and Raji cells

Cancer Letters

A short-term in vitro assay for promoter substances using human lymphoblastoid cells latently infected with Epstein-Barr virus

Cancer Letters

Epstein-Barr virus activation by tung oil, extracts of Aleurites fordii and its diterpene ester 12-O-hexadecanoyl-16-hydroxyphorbol-13-acetate

Cancer Letters

Search for possible antitumor promoters by inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation; ursolic acid and oleanolic acid from an anti-inflammatory Chinese medicinal plant, Glechoma hederaceae L.

Cancer Letters

Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced induction in Epstein-Barr virus early antigen in Raji cells

Cancer Letters

The Epstein-Barr virus early antigen inducing indole alkaloids, (−)-indolactam V and its related compounds, produced by Actinomycetes

Agric. Biol. Chem.

Differential inhibitory effects of retinoic acid on Epstein-Barr virus induction in producer and non-producer cell lines

Intervirology

Antitumor-promoting activity of glycyrrhetic acid in mouse skin tumor formation induced by 7,12-dimethylbenz(a)-anthracene plus teleocidin

Carcinogenesis

Cited by (285)

Design, modification of phyllanthone derivatives as anti-diabetic and cytotoxic agents

Pyrola incarnata demonstrates neuroprotective effects against β-amyloid-induced memory impairment in mice

2,6-Dimethoxy-1,4-benzoquinone, isolation and identification of anti-carcinogenic, anti-mutagenic and anti-inflammatory component from the juice of Vitis coignetiae

A triterpenoid commonly found in human diet: Ursolic acid

Efficacy of herbal medicine as adjunctive therapy for skin cancer

Compositional characteristics of glucuronide conjugates in regional glechoma hederacea var. Longituba herbal extracts using a set of polyphenolic marker compounds

Research letterInhibitory effects of ursolic and oleanolic ancid on skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate

Abstract

Cancer Letters

Cancer Letters

Cancer Letters

Cancer Letters

Cancer Letters

The Epstein-Barr virus early antigen inducing indole alkaloids, (−)-indolactam V and its related compounds, produced by Actinomycetes

Agric. Biol. Chem.

Differential inhibitory effects of retinoic acid on Epstein-Barr virus induction in producer and non-producer cell lines

Intervirology

Antitumor-promoting activity of glycyrrhetic acid in mouse skin tumor formation induced by 7,12-dimethylbenz(a)-anthracene plus teleocidin

Carcinogenesis

Research letter
Inhibitory effects of ursolic and oleanolic ancid on skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate