Cancer Letters

Cancer Letters

Volume 90, Issue 1, 23 March 1995, Pages 65-73
Cancer Letters

Tenascin in breast cancer development — is epithelial tenascin a marker for poor prognosis?

https://doi.org/10.1016/0304-3835(94)03679-DGet rights and content

Abstract

(1) In mouse mammary gland development, immunoreactive tenascin (TN) is expressed in the dense mesenchyme surrounding the epithelial component of 14-day embryos, endbuds at puberty, and tumors. (2) Cells that produce TN are myofibroblastic and are characterized by nuclear invaginations, rough endoplasmic reticulum, and pinocytotic vesicles. These cells are not normally present in the stroma of mammary glands but present in cancer stroma, originating probably from fibroblasts differentiated under the influence of TGF-β1 stimulation. (3) Breast cancer cells are capable of synthesing TN under certain conditions. TN-non-producing MCF7 cells can produce TN when co-cultured with embryonic fibroblasts or with their conditioned medium. (4) Nine primary human breast cancers were examined for TN expression by in situ hybridization. TN mRNA was expressed in all nine cases in the stroma and in four cases in carcinoma cells as well. (5) Immunohistochemistry for TN was performed in human breast cancers, and it was found that the five-year survival after surgery was markedly lower in the group whose cancer cells were negative for TN. TN expression in cancer cells appears to indicate poor prognosis.

References (50)

  • G.K. Koukoulis et al.

    Tenascin in normal, reactive, hyperplastic, and neoplastic tissues: biologic and pathologic implications

    Hum. Pathol.

    (1991)
  • J.E. Ferguson et al.

    Tenascin distribution in the normal breast is altered during the menstrual cycle and in carcinoma

    Differentiation

    (1990)
  • V.E. Gould et al.

    Extracellular matrix proteins and their receptors in the normal, hyperplastic and neoplastic breast

    Cell Diff. Dev.

    (1990)
  • M. Koch et al.

    Epithelial synthesis of tenascin at tips of growing bronchi and graded accumulation in basement membrane and mesenchyme

    Exp. Cell Res.

    (1991)
  • B.G. Sharifi et al.

    Angiotensin-II regulates tenascin gene expression in vascular smooth muscle cells

    J. Biol. Chem.

    (1992)
  • C. Grobstein

    Tissue interaction in the morphogenesis of mouse embryonic rudiments in vitro

  • M. Chiquet et al.

    Chick myotendinous antigen. I. A monoclonal antibody as a marker for tendon and muscle morphogenesis

    J. Cell Biol.

    (1984)
  • M.A. Bourdon et al.

    Human gliomamesenchymal extracellular matrix antigen defined by monoclonal antibody

    Cancer Res.

    (1983)
  • H.P. Erickson et al.

    A six armed oligomer isolated from cell surface fibronectin preparations

    Nature

    (1984)
  • J. Kruse et al.

    The J1 glycoprotein — a novel nervous system cell adhesion molecule of the L2/HNK-1 family

    Nature

    (1985)
  • M. Grumet et al.

    Cytotactin, and extracellular matrix protein of neural and non-neural tissues that mediates glianeuron interaction

  • E.J. Mackie et al.

    Tenascin is a stromal marker for epithelial malignancy in the mammary gland

  • Y. Saga et al.

    Mice develop normally without tenascin

    Genes and Dev.

    (1992)
  • Y. Morel et al.

    Transcript encoded on the opposite strand of the steroid 21-hydroxylase/complement component C4 gene locus

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