Elsevier

Neuroscience Letters

Volume 16, Issue 3, March 1980, Pages 235-238
Neuroscience Letters

Myelination in rabbit optic nerves is accelerated by artificial eye opening

https://doi.org/10.1016/0304-3940(80)90003-8Get rights and content

Abstract

Artificial opening of the eyes of young rabbits on the 5th postnatal day led to accelerated myelination: the myelin-specific basic and proteolipid proteins nearly doubled between the 7th and the 10th postnatal days when compared to controls; 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNP) activity also increased by about 60%. Conversely, lowered AChE activities presumably reflected elevated myelin/axolemma ratios. Myelination in treated animals normalized during later ontogenetic stages (> 20th postnatal day).

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