Elsevier

Neuroscience Letters

Volume 164, Issues 1–2, 24 December 1993, Pages 44-46
Neuroscience Letters

Immunohistochemical localization of transforming growth factor-α in choroid plexus of the rat and chicken

https://doi.org/10.1016/0304-3940(93)90853-DGet rights and content

Abstract

Transforming growth factor-α (TGF-α) is a polypeptide which binds to epidermal growth factor-receptor (EGF-R) to carry out its function. We have observed strong TGF-α immunoreactivity in the developing and adult choroid plexus of the rat and chicken and glial cells of adult rats, by using a well characterized monoclonal antibody and the peroxidase method. Preabsortion of the antibody with the peptide gave negative staining. Since previous studies have shown that EGF-R is localized in several brain regions, but not in the choroid plexus, during development and adulthood, it is suggested that TGF-α, synthesized in the choroid plexus and transferred to the cerebrospinal fluid, has a role in brain development. TGF-α immunoreactivity found in glial cells, but not in neurons of adult rats, suggests that TGF-α in adulthood is also synthetized in the glial cell compartment.

Cited by (0)

View full text