Prostacyclin (PGI2) protects rat cortical neurons in culture against hypoxia/reoxygenation and glutamate-induced injury

doi:10.1016/0304-3940(93)90924-A

Neuroscience Letters

Volume 160, Issue 1, 17 September 1993, Pages 106-108

https://doi.org/10.1016/0304-3940(93)90924-A Get rights and content

Abstract

Arachidonic acid and its metabolites are released in brain extracellular fluids as a result of ischemia and may participate in either damaging or protecting neural tissues. This study investigates the neuroprotective effect of prostacyclin (PGI₂) on hypoxia (5 h)/reoxygenation (3 h) and on the excitotoxic neurotransmitter, glutamate (10 μM), in rat cortical neuron cultures. At μM concentrations, PGI₂ inhibits lactate dehydrogenase release, a cell-injury marker. These results, showing a direct cytoprotective effect of PGI₂ on brain cells, reinforce its beneficial properties on vessels and circulating cells in cerebral ischemia.

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Prostacyclin (PGI2) protects rat cortical neurons in culture against hypoxia/reoxygenation and glutamate-induced injury

Abstract

Prostaglandins

Prostaglandins

Kidney Int.

Histochemical and biochemical studies on the effect of the prostacyclin derivative Iloprost on CCl4-induced lipid peroxidation in rat liver and its significance for hepatoprotection

Hepatology

Superoxide and nitric oxide cooperation in hypoxia/reoxygenation-induced neuron injury

Free Radic. Biol. Med.

Reduction of γ-aminobutyric acid and glutamate uptake and (Na++K+)-ATPase activity in brain slices and synaptosomes by arachidonic acid

J. Neurochem.

Intravenous prostacyclin in acute nonhemorrhagic stroke: a placebo-controlled double-blind trial

Stroke

Prostacyclin (PGI₂) protects rat cortical neurons in culture against hypoxia/reoxygenation and glutamate-induced injury

Histochemical and biochemical studies on the effect of the prostacyclin derivative Iloprost on CCl₄-induced lipid peroxidation in rat liver and its significance for hepatoprotection

Reduction of γ-aminobutyric acid and glutamate uptake and (Na⁺+K⁺)-ATPase activity in brain slices and synaptosomes by arachidonic acid