Are disturbances in opioid and adrenergic systems involved in the hormonal dysfunction of anorexia nervosa?

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Abstract

Opioid peptides and catecholamines play an important role in the control of appetite, behaviour and hormonal secretion. To evaluate the role of the opioid and adrenergic systems in the hormonal dysfunction of anorexia nervosa (AN), we investigated the effects of naloxone and clonidine on serum GH, LH, FSH, β-endorphin, TSH, prolactin and cortisol concentrations in 35 women with AN.

Basal plasma β-endorphin concentrations were significantly lower than those in healthy controls. The response of β-endorphin to clonidine in the AN patients was increased, whereas the response of β-endorphin to naloxone was decreased.

Basal serum cortisol concentrations were significantly higher in the AN patients than that in the controls. There was significant increase in the cortisol response to naloxone in the controls but a lack of cortisol response to naloxone in the patients with AN.

Naloxone produced a significant increase in LH release in the controls during the luteal phase of the menstrual cycle, as well as in the majority of AN patients. Clonidine caused a diminution of LH in the controls and did not alter LH in the patients. After clonidine injection, a significant increase in GH release was observed in both groups of subjects. If these disturbances persist after normalization of body weight, it might suggest that altered opioid and adrenergic activity is an aetiological factor in the pathogenesis of anorexia nervosa.

References (36)

  • R Lanes et al.

    Decreased secretion of cortisol and ACTH after oral clonidine administration in normal adults

    Metabolism

    (1983)
  • MP Warren et al.

    Clinical and metabolic features of anorexia nervosa

    Am J Obstet Gynecol

    (1973)
  • GK Aghajanian

    Regulation of central noradrenergic cell firing: role of α2-adrenoceptors and opiate receptors

  • A Arc et al.

    Hypothalamic endocrine dysfunction in anorexia nervosa

    Acta Endocrinol

    (1977)
  • RL Atkinson

    Naloxone decreases food intake in obese humans

    J Clin Endocrinol Metab

    (1982)
  • B Baranowska

    The effect of clonidine on hormone release mediated through activation of opiate receptors

    Cardiovasc Drugs Ther

    (1990)
  • B Baranowska et al.

    Some aspects of hypothalamo-pituitary function anorexia nervosa

  • B Baranowska et al.

    The role of endogenous opiates in the mechanism of inhibited luteinizing hormone (LH) secretion in women with anorexia nervosa: the effect of naloxone on LH, follicle-stimulating hormone, prolactin and β-endorphin secretion

    J Clin Endocrinol Metab

    (1984)
  • B Baranowska et al.

    The opposite effect of naloxone and clonidine on β-endorphin, cortisol, TSH and LH release in healthy subjects

    Neuroendocrinol Lett

    (1985)
  • B Baranowska et al.

    Exaggerated response of GH to GRF in patients with anorexia nervosa

    Neuroendocrinol Lett

    (1986)
  • RM Boyar et al.

    Anorexia nervosa: immaturity of the 24-hour luteinizing hormone secretory pattern

    N Engl J Med

    (1974)
  • C Braestrup et al.

    Regulation in the central norepinephrine neurotransmission induced in vivo by alpha adrenoceptor active drugs

    J Pharmacol Exp Ther

    (1976)
  • M Bramnert et al.

    Partial blockade by naloxone of clonidine-induced increase in plasma growth hormone in hypertensive patients

    J Clin Endocrinol Metab

    (1984)
  • RC Casper et al.

    Alterations in serum cortisol and its binding characteristics in anorexia nervosa

    J Clin Endocrinol Metab

    (1979)
  • JW Chambers et al.

    Neurotransmitter regulation of growth hormone and ACTH in Rhesus monkey. Effects of biogenic amines

    Endocrinology

    (1976)
  • G Delitala et al.

    Opiate receptors and anterior pituitary hormone secretion in man. Effect of naloxone infusion

    Acta Endocrinol

    (1981)
  • SP Feighner et al.

    Diagnostic criteria for use in psychiatric research

    Arch Gen Psychiatry

    (1972)
  • RJ Frankel et al.

    Hypothalamo-pituitary function in anorexia nervosa

    Acta Endocrinol

    (1975)
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