Novel use of a chimpanzee pseudogene for chromosomal mapping of human cytochrome oxidase subunitIV
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MULocDeep: A deep-learning framework for protein subcellular and suborganellar localization prediction with residue-level interpretation
2021, Computational and Structural Biotechnology JournalCitation Excerpt :Firstly, we used several proteins with known localization signals as cases to demonstrate the ability of attention weights for indicating the contribution of each amino acid in localization. The proteins are: SV40 large T antigen (P03070) located at the nucleus, with the known signal motif “PKKKRKV” in the middle of the protein sequence; lactalbumin (P09462) located at the secreted pathway, with a known signal peptide “MMSFVSLLLVGILFWATEAEQLTKCEVFQ” at the N-terminus; and COX4 (P04037) located in the mitochondrial inner membrane, with the known transit peptide “MLSLRQSIRFFKPATRTLCSSRYLL” at the N-terminus [49–51]. When using these proteins as input, MULocDeep predicted the localization correctly for all three proteins.
Mitochondrial Medicine: The Mitochondrial Biology and Genetics of Metabolic and Degenerative Diseases, Cancer, and Aging
2013, Emery and Rimoin's Principles and Practice of Medical GeneticsNuclear genes for cytochrome c oxidase
1997, Biochimica et Biophysica Acta - Gene Structure and ExpressionCytochrome c oxidase: Tissue-specific expression of isoforms and regulation of activity
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Present addresses: (B.T.D.) Department of Pediatrics, New England Medical Center, Boston, MA 02111 (U.S.A.) Tel. (617)956-5348; (U.F.) Howard Hughes Medical Institute, Beckman Center for Molecular and Genetic Medicine, Stanford University Medical Center, Stanford, CA 94305 (U.S.A.) Tel. (415)725-8089.