Identification of homeobox genes expressed in human haemopoietic progenitor cells
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Up-regulated lncRNA-MSX2P1 promotes the growth of IL-22-stimulated keratinocytes by inhibiting miR-6731-5p and activating S100A7
2018, Experimental Cell ResearchCitation Excerpt :One such lncRNA, lncRNA-MSX2P1 is up-regulated in HaCaT cells treated with IL-22 compared with HaCaT control. MSX2P1 is associated with the Msx gene family [24]. S100A7 (psoriasin), a member of the S100 gene family [25], is overexpressed in inflammatory diseases.
LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis
2018, BloodCitation Excerpt :The mixed lineage leukemia (MLL) gene is the mammalian homolog to Drosophila trithorax and is a master regulator of the clustered homeotic (HOX) genes.1-5
Isolated Hoxa9 overexpression predisposes to the development of lymphoid but not myeloid leukemia
2013, Experimental HematologyNUP98 gene fusions and hematopoietic malignancies: Common themes and new biologic insights
2011, BloodCitation Excerpt :Although all 11 of the Hoxa cluster genes are expressed in murine HSCs, the most highly expressed and differentially regulated genes are Hoxa5, a7, a9, and a10.77 In general, these 4 Hoxa genes are most highly expressed in the hematopoietic stem and progenitor cells (HSPCs), and they seem to regulate HSPC self-renewal and repopulation of early myeloid and lymphoid progenitors.78-83 As progenitor cells proliferate and differentiate, thus losing their self-renewal properties, these 4 Hoxa cluster genes are down-regulated, as is the Hox cofactor Meis1.78,79,84
Hemogenic endothelium: Origins, regulation, and implications for vascular biology
2011, Seminars in Cell and Developmental BiologyCitation Excerpt :Moreover, their role in normal hematopoiesis has also been extensively studied. Analysis of bone marrow samples from both murine and human show that hematopoietic cells express genes in the Hox A, B, C and D clusters [162–164]. Studies have also shown that HoxB4 is a potent stimulator of HSC expansion [165–168].
Overexpression of stem cell associated ALDH1A1, a target of the leukemogenic transcription factor TLX1/HOX11, inhibits lymphopoiesis and promotes myelopoiesis in murine hematopoietic progenitors
2008, Leukemia ResearchCitation Excerpt :Thus, HSC differentiation appears to depend heavily on RA synthesized by ALDH1A1, a role that would explain the abundance of this enzyme in early hematopoietic precursors. Although TLX1 is not expressed within committed lineages of the hematopoietic system, accumulating evidence indicates that it is transcribed in CD34+ precursor cells [65,66]. It is therefore plausible that ALDH1A1 is regulated by TLX1 in HSCs with both being downregulated during differentiation.