Short communicationThe 3′-untranslated regions from the Trypanosoma brucei phosphoglycerate kinase-encoding genes mediate developmental regulation
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Cited by (52)
Leishmania major phosphoglycerate kinase transcript and protein stability contributes to differences in isoform expression levels
2015, Experimental ParasitologyCitation Excerpt :Most likely, PGKB and PGKC divergent sequences within the untranslated regions are involved in the control of transcript stability. Accumulating evidence indicates that the regulation of gene expression in trypanosomatids is determined at the posttranscriptional level, and several studies have demonstrated that 3′-UTRs play major roles in the control of mRNA stability and the protein translation rate (Abanades et al., 2009; Blattner and Clayton, 1995; De Gaudenzi et al., 2013; Pérez-Díaz et al., 2013; Suganuma et al., 2012). Fewer reports are available that indicate that 5′-UTR elements and in some cases intergenic regions (IR) also play roles in posttranscriptional mechanisms of gene expression regulation (Jaeger and Brandao, 2011; Mahmood and Ray, 1998).
Transcriptomics and proteomics in human African trypanosomiasis: Current status and perspectives
2011, Journal of ProteomicsCitation Excerpt :In addition to investigations on the temporally regulated transcripts, studies analyzing the mRNA expression profiles between bloodstream and procyclic forms [68,71–73,77] have shown that the number of life-cycle-regulated genes is estimated at 1–14% of the genome [71,73,91]. Most upregulated genes in the bloodstream forms encode proteins involved in the transport across membranes and electron transport [71,92], the glycolysis [93], the proteolysis [77], the ATP binding [71,74], the protein and DNA binding [77], the protein folding [77], the microtubule activity [71], and proteins involved in other metabolic processes [77]. Other transcripts upregulated in the bloodstream forms encode for abundant surface protein or membrane proteins [67,71–73,94–99], a considerable number of hypothetical proteins, and proteins with unknown biological functions [71–73,99] (Table 2).
Differential expression of a protease gene family in African trypanosomes
2009, Molecular and Biochemical ParasitologyControl and regulation of gene expression: Quantitative analysis of the expression of phosphoglycerate kinase in bloodstream form Trypanosoma brucei
2008, Journal of Biological ChemistryRegulated expression of glycosomal phosphoglycerate kinase in Trypanosoma brucei
2007, Molecular and Biochemical Parasitology