Elsevier

Gene

Volume 174, Issue 1, 26 September 1996, Pages 129-134
Gene

Molecular cloning of two novel rab genes from human melanocytes

https://doi.org/10.1016/0378-1119(96)00509-4Get rights and content

Abstract

We isolated the genes of two small GTP-binding proteins of the rab family from a human melanocyte cDNA library and from melanoma cells. One gene, rab30 codes for a novel rab protein of 203 amino acids with minimal homology to previously documented GTPases. The other, rab22b, appears to be an isoform of the human homologue of canine rab22. Both rab mRNAs displayed a nearly ubiquitous pattern of expression in the various tissues examined. Rab22b and rab30 were mapped to chromosomes 18 and 11, respectively.

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