NoteThe effect of batch size on scale-up of a pharmaceutical granulation in a fixed bowl mixer granulator
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Cited by (32)
DEM study of mixing behaviours of cohesive particles in a U-shaped ribbon mixer
2022, Powder TechnologyCitation Excerpt :The torque tends to increase with the increase of particle cohesion. The increase of impeller torque is attributed to the destruction and recombination of the liquid bridge, which has been proven in many previous experimental and numerical studies [47–51]. The results imply that the impeller receives a higher load from the particles with increased cohesion.
A quality by design approach to scale-up of high shear wet granulation process
2018, Handbook of Pharmaceutical Wet Granulation: Theory and Practice in a Quality by Design ParadigmA comprehensive review on process and engineering aspects of pharmaceutical wet granulation
2017, Chemical Engineering JournalDesign, development, and scale-up of the high-shear wet granulation process
2017, Developing Solid Oral Dosage Forms: Pharmaceutical Theory and Practice: Second EditionArtificial Intelligence Tools for Scaling Up of High Shear Wet Granulation Process
2017, Journal of Pharmaceutical SciencesCitation Excerpt :All results are shown in Table 1. Following the methodology previously suggested by several authors5,6 for predicting the behavior of plant scale equipment from information generated at laboratory scale machines, 3 dimensionless numbers were calculated. The Power number (Np) is defined as ΔPg/ρN3D5, the Reynolds number (NRe) is defined as D2Nρ/η, and the Froude number (NFr) is defined as N2D/g, were ΔP is the differential impeller power (W), N the impeller speed (rps), D the impeller diameter (m), g the gravity (9.8 m/s2), ρ the wet mass bulk density (kg/m3), and η (Nm) the wet mass consistency obtained by mixer torque rheometry.