Single unit clues to cochlear mechanisms
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Cited by (80)
A multi-metric approach to characterizing mouse peripheral auditory nerve function using the auditory brainstem response
2020, Journal of Neuroscience MethodsCitation Excerpt :As sound levels increase above threshold, additional high-SR fibers with CF’s that differ from the frequency of the eliciting stimulus, called off-frequency fibers, are recruited and this contributes to an increase in the overall AN population response amplitude. Due to the asymmetric shape of the tuning curves of the AN fibers (Kiang et al., 1986; Temchin et al., 2008), the majority of these neighboring off-frequency fibers are located more basal-ward in the cochlear partition (i.e., have a higher CF than the eliciting stimulus). These higher-CF fibers have relatively shorter latencies because of the basilar membrane’s traveling wave delay (Kiang et al., 1965), and thus the recruitment of off-frequency fibers with increasing stimulus levels contributes to an overall decrease in the latency of the AN response.
2.21 - Mechanics of the Cochlea
2020, The Senses: A Comprehensive Reference: Volume 1-7, Second EditionTonotopy in calcium homeostasis and vulnerability of cochlear hair cells
2019, Hearing ResearchCitation Excerpt :This selectivity towards OHCs was especially apparent after treatment with aminoglycoside antibiotics such as kanamycin, prolonged treatment with which produced OHC degeneration and substantial threshold elevation (Ryan et al., 1980). The selective effects of kanamycin were used to conclude that OHCs are responsible for high sensitivity and sharp frequency tuning of the auditory periphery (Dallos and Harris, 1978; Kiang et al., 1986), properties distinct from IHCs, which transmit the acoustic signals via synapses on auditory nerve terminals. It was later demonstrated that the unique property of OHCs to mechanically amplify the acoustic input by force generation stems from the piezoelectric protein prestin present at high density in their lateral membranes (Dallos et al., 2008; Zheng et al., 2000).
How are inner hair cells stimulated? Evidence for multiple mechanical drives
2012, Hearing ResearchSpectral Processing by the Peripheral Auditory System: Facts and Models
2005, International Review of NeurobiologyCitation Excerpt :Another level‐dependent aspect of AN phase responses is related to what is known as “Nelson's notch.” Nelson Kiang and colleagues (e.g., Kiang et al., 1986) reported that the discharge rate of AN fibers decreased drastically from saturation values to a value near the spontaneous rate and back again to saturation rates all within a range of levels between 90 to 100 dB SPL. This result occurs only for certain combinations of CF and stimulus frequency and always coincides with a rapid change in phase of approximately 180° over a 10‐dB range.