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2021, Hearing ResearchCitation Excerpt :An example is using furosemide to reversibly block the Na, K, Cl cotransporter (Sewell, 1984a). Second, aging can affect battery performance by reducing the density of active pumps in the cell membrane or by reducing the overall pump-containing membrane area in the stria vascularis (Gratton, et al., 1995a,b; 1996; 1997a,b; Schulte and Schmiedt, 1992). Third, the model predicts that the EP is modulated by the overall load resistance of the OHC system.
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2020, Hearing ResearchCitation Excerpt :Our study also revealed an important auditory hallmark of hearing impairment in the GASH/Sal that exhibited mild atrophy of the SV. Since strial dysfunction is associated to age-related hearing loss and alteration of cochlear homeostasis (Schuknecht et al., 1974; Gratton and Schulte, 1995; Patuzzi, 2011), the reduced SV thickness and fewer strial capillaries in the GASH/Sal might underlie the abnormalities of the organ of Corti and cause important disturbances in sound transduction. Our molecular study further revealed concomitant molecular disruptions in the expression of cochlear genes that are involved in the mechanotransduction.
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