Effect of brahmi rasayan on the central nervous system

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Abstract

Brahmi Rasayan, an Ayurvedic preparation, was studied in mice and rats for its effects on the central nervous system at oral doses ranging between 1 and 30 g/kg. Observational screening in mice was carried out following a multiparametric check list. The test material was studied for its effect on pentobarbitone hypnosis, motor co-ordination, tail-withdrawal reaction time, electroshock, chemoconvulsions, haloperidol-induced catalepsy and conditioned avoidance response. The test material exhibited a sedative effect and significantly prolonged the hypnotic action of pentobarbitone. It produced a variable blockade of conditioned avoidance response. The presence of a significant antinociceptive effect, coupled with the ability of the test substance to offer protection against electroshock seizures and chemoconvulsions plus the ability to antagonize the haloperidol-induced catalepsy, suggests an involvement of the GABA-ergic system in the mediation of the central nervous system effects of Brahmi Rasayan.

References (32)

  • E. Cósta et al.

    New concepts on the mechanism of action of benzodiazepines

    Life Science

    (1975)
  • I. Creese et al.

    Dopamine receptor binding predicts clinical and pharmacological potencies of anti-schizophrenic drugs

    Science

    (1976)
  • P.C. Dandiya et al.

    Studies on Acorcus calamus (III): some pharmacological actions of the volatile oil

    Journal of Pharmacology and Experimental Therapeutics

    (1959)
  • O.L. Davies et al.

    A method for the evaluation of analgesic activity using rats

    British Journal of Pharmacology

    (1946)
  • L.S. Goodman et al.

    Comparison of maximal seizures evoked by pentylenetetrazol (Metrazol) and electroshock in mice and their modification by anticonvulsants

    Journal of Pharmacology and Experimental Therapeutics

    (1953)
  • W. Haefely

    Facilitation of GABA-ergic transmission by drugs

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