Original contributionKetamine in the treatment of bronchospasm during mechanical ventilation☆
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Cited by (42)
Severe Bronchospasm During Separation from Cardiopulmonary Bypass: Diagnosis, Etiology, and Treatment
2022, Journal of Cardiothoracic and Vascular AnesthesiaCitation Excerpt :Circuit obstruction, misplacement of the endotracheal tube, and mucous plugging immediately were ruled out, and the patient received nearly every form of therapy for refractory bronchospasm, including endotracheal albuterol and epinephrine, deep volatile anesthetic, intravenous epinephrine and methylprednisolone, and initiation of a propofol infusion. It has been well-described that ketamine can be used for refractory bronchospasm due to its bronchodilatory effects and resulting increase in circulating catecholamines.1,9 Ketamine was considered, but ultimately was not administered, as the patient remained hemodynamically stable on a low-dose epinephrine infusion and the authors wanted to avoid the sympathetic effects and potential increase in pulmonary vascular resistance in the context of a Ross procedure.
High-Risk Airway Management in the Emergency Department. Part I: Diseases and Approaches
2020, Journal of Emergency MedicinePharmacokinetics of Ketamine at Dissociative Doses in an Adult Patient With Refractory Status Asthmaticus Receiving Extracorporeal Membrane Oxygenation Therapy
2019, Clinical TherapeuticsCitation Excerpt :These unique pharmacokinetic and pharmacodynamic properties make ketamine a useful agent for the initial management of severe asthma exacerbations that require intubation. In cases where patients present with severe asthma exacerbations unresponsive to conventional therapy that require emergency intubation, ketamine was reported to improve clinical and laboratory values after repeated administration.12–14 Infusion doses associated with efficacy ranged from 0.75 to 3 mg/kg/h.13–15 These reports may suggest a dose-dependent bronchodilatory response often not seen with subanesthetic doses used in acute pain management.
Induction techniques for pediatric patients with congenital heart disease undergoing noncardiac procedures are influenced by cardiac functional status and residual lesion burden
2018, Journal of Clinical AnesthesiaCitation Excerpt :In the absence of hypoxemia, ketamine has been shown to have minimal effect on pulmonary vascular resistance in patients with pulmonary hypertension [13]. Although ketamine can act as a bronchodilator, used for refractory bronchospasm [19, 20], its use is associated with laryngospasm [21, 22]. Sevoflurane in 1 or 1.5 MAC concentrations mildly depresses left ventricular systolic function and does not change Qp:Qs in patients with isolated atrial or ventricular septal defects [15].
Pharmacology of intravenous anesthetics
2018, Pharmacology and Physiology for Anesthesia: Foundations and Clinical ApplicationPhysiologic and Pathophysiologic Responses to Intubation
2013, Benumof and Hagberg's Airway Management
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Data were presented at the 66th congress of the International Anesthesia Research Society, San Francisco, CA, March 1992.