Neurobehavioral studies of ethanol reward and activation
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Cited by (78)
Dose-dependent effects of alcohol administration on behavioral profiles in the MCSF test
2016, AlcoholCitation Excerpt :Individuals who perceive the drug as more rewarding and less aversive may be at higher risk for AUDs (Hendler et al., 2013; Schuckit, Smith, & Kalmijn, 2004). Although generally considered to be a sedative or depressant drug, alcohol has a biphasic effect with both stimulatory and depressant effects on behavior depending on dose and time (Brabant, Guarnieri, & Quertemont, 2014; Lewis & June, 1990; Pohorecky, 1977). In rodents, alcohol-induced locomotor activation has been considered an index of the appetitive, rewarding effects of the drug (Brabant et al., 2014; Camarini et al., 2010), and there are studies indicating positive relationships between locomotor activation and alcohol preference (Waller, Murphy, McBride, Lumeng, & Li, 1986).
Adolescent intermittent ethanol exposure diminishes anhedonia during ethanol withdrawal in adulthood
2014, European NeuropsychopharmacologyCitation Excerpt :Enhanced brain reward function by acute ethanol in mice (e.g., Fish et al., 2012) and selectively bred alcohol-preferring rats (Eiler et al., 2007) may not generalize to outbred rat strains. Additionally, some studies used uncommon ICSS procedures (Lewis and June, 1990, 1994; Musgrave et al., 1989) or inferred reward enhancement from increased response rates (rate–frequency procedures; Bain and Kornetsky, 1989; de Witte and Bada, 1983). In the present study, we assessed the effects of ethanol on brain reward function using the rate-free discrete-trial current-threshold procedure (Kornetsky et al., 1979; Markou and Koob,1992).
Locomotor activity assay in zebrafish larvae: Influence of age, strain and ethanol
2012, Neurotoxicology and TeratologyCitation Excerpt :Ethanol, a known drug of abuse with various effects on histological and behavioural level in humans, has been shown to increase as well as decrease motor activity in both humans and rodents. These effects on activity seem to depend on a number of experimental parameters, e.g. species and strain, dose of ethanol, time of consumption (Lewis and June, 1990; Tabakoff and Kiianmaa, 1982; Masur et al., 1986; Masur and dos Santos, 1988; Selderslaghs et al., 2010; Sylvain et al., 2010; Camarini et al., 2010; Jerlhag et al., 2010). The effects of ethanol on the swimming activity of zebrafish larvae have been investigated and it has been shown that exposure to low doses (0.5–2%) causes an increased swimming activity, while a decreased activity has been observed after exposure to high doses (4%) (MacPhail et al., 2009; Irons et al., 2009; Lockwood et al., 2004).
Alcohol and nutrient intake: Mechanisms of reinforcement and dependence
2011, Physiology and BehaviorCitation Excerpt :These effects also correspond to the period when alcohol enhances locomotor activity and BSR. Previous research [7] shows that low doses of alcohol decrease the threshold for electrical brain stimulation reward (BSR). Moreover, Lewis and June [8] show that when low doses of alcohol are combined with cocaine, a drug known to enhance synaptic DA levels, BSR performance is enhanced.
Brain Stimulation and Addiction
2010, Encyclopedia of Behavioral Neuroscience, Three-Volume Set, 1-3