Localization of the human erbB-2 gene on normal and rearranged chromosomes 17 to bands q12–21.32☆
References (23)
- et al.
Myc oncogenes: Activation and amplification
Biochim. Biophys. Acta
(1987) - et al.
Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185
Cell
(1986) - et al.
Molecular basis of human B cell neoplasia
Blood
(1985) - et al.
Constitutional t(15;17): Clarification of the chromosomal breakpoints
Cancer Genet. Cytogenet
(1986) - et al.
The myeloperoxidase gene is translocated from chromosome 17 to 15 in a patient with acute promyelocytic leukemia
Cancer Genet. Cytogenet
(1988) - et al.
Localization of the human myeloperoxidase gene is in close proximity to the translocation breakpoint in acute promyelocytic leukemia
Leukemia
(1987) - et al.
Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene
Science
(1985) - et al.
A human c-erbA oncogene homologue is closely proximal to the chromosome 17 breakpoint in acute promyelocytic leukemia
- et al.
ErbB-2 is a potent oncogene when overexpressed in cells
Science
(1987) - et al.
Constitutional t(15;17)
Cancer Genet. Cytogenet
(1981)
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Sequence data from this article have been deposited with the EMBL/GenBank Data Libraries under Accession No. J03067.