Research reportEstradiol replacement facilitates the acquisition of seizures kindled from the anterior neocortex in female rats
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2019, International Journal of PharmaceuticsCitation Excerpt :LET-NE significantly reduced the 17β-estradiol levels in the hippocampus. Various research studies have shown the proconvulsant effects of 17β-estradiol (Buterbaugh, 1989; Woolley, 2000). Therefore, it is probable that the anticonvulsant effect of LET-NE is via inhibiting the conversion of testosterone into 17β-estradiol.
Aromatase inhibition by letrozole attenuates kainic acid-induced seizures but not neurotoxicity in mice
2018, Epilepsy ResearchCitation Excerpt :The role of estrogens in etiology of epilepsy is still not understood (Scharfman and MacLusky, 2006). In several studies, estrogens have shown to exacerbate seizures, for instance, in PTZ-kindled, amygdala-kindled and KA-induced seizures in rodents (Buterbaugh, 1989; Woolley, 2000). Clinically too, estrogens enhance seizures in females suffering from epilepsy (Backstrom, 1976; Morrell, 1999).
Seizure facilitating activity of the oral contraceptive ethinyl estradiol
2016, Epilepsy ResearchRaloxifene protects against seizures and neurodegeneration in a mouse model mimicking epilepsy in postmenopausal woman
2014, European Journal of Pharmaceutical SciencesFemale ovarian steroids in epilepsy: A cause or remedy
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