Macrophages in tissues and in vitro
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Cited by (72)
The enhancing immune response and anti-inflammatory effects of Anemarrhena asphodeloides extract in RAW 264.7 cells
2019, PhytomedicineCitation Excerpt :It is well known that the immune response is classified into the innate and adaptive immune systems; it plays an important role in the defense system of the host (Janeway et al., 2001; Kumar et al., 2014). To protect the body against infection by foreign pathogens, the innate immune response rapidly promotes defense mechanisms including the recruitment of immune cells, production of cytokines, clearance of pathogens and infected or dead cells, and activation of the adaptive immune system (Gordon et al., 1992; Janeway et al., 2001). Innate immune cells, including neutrophils, dendritic cells, and macrophages, initiate the inflammatory response by increasing the production of nitric oxide (NO), reactive oxygen species (ROS), and inflammatory cytokines (Moreira et al., 2001; Wu et al., 2008).
Bioanalytical chemistry of cytokines - A review
2015, Analytica Chimica ActaCitation Excerpt :Cytokines are pleiotropic which refers to their ability to address multiple targets and physiological effects as shown in Fig. 1. The term cytokine redundancy is associated with cytokine pleiotropy and is a common feature of some cytokines [7]. The physiological effects of cytokines often depend on the relative concentrations of several cytokines [8].
Macrophage immunoregulatory pathways in tuberculosis
2014, Seminars in ImmunologyCitation Excerpt :Macrophages have been categorized into two major groups: the pro-inflammatory, “classically” activated M1 type macrophage and the immunoregulatory, “alternatively” activated M2 type macrophage [56,57]. However, it is increasingly clear that macrophage function represents a spectrum, with biological activities varying greatly among mammalian species and experimental stimuli [7,58–65]. For example, mouse macrophages express unique phenotypic markers for M1/M2, not expressed by human macrophages [57,61].
An ultrastructural study, effects of Proteus vulgaris OX19 on the rabbit spleen cells
2013, MicronCitation Excerpt :Extracellular molecules such as proteins and polysaccharides are taken into macrophages by phagocytosis and undergoes metabolic changes. These molecules may be free or found in the structure of microorganisms (Gordon et al., 1992; Paulnock, 1992). The phagocytes are also active in removal of other particulate matter from the blood such as bacteria, cell debris and abnormal macromolecules produced in some of the diseases (Cotran et al., 1999).
Effects of Rapamycin on the Differentiation and Function of Macrophages In Vitro
2009, Agricultural Sciences in ChinaConverging Cell Therapy with Biomaterials
2007, Cellular Transplantation
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S Gordon, I Fraser, D Nath, D Hughes, S Clarke, Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, UK.