Vitronectin and its receptors
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Matricellular proteins in atherosclerosis development
2023, Matrix BiologyMaterial-driven fibronectin and vitronectin assembly enhances BMP-2 presentation and osteogenesis
2022, Materials Today BioCitation Excerpt :Its biological functions are dependent on the conformation of its secondary structure. Upon undergoing a conformational change from monomeric form to multimeric form, VN becomes more biologically active by exposing its heparin-binding and cell-binding sites [17–19]. In particular, the cellular αV integrins are shown to couple with cell-binding sites of VN [20].
Identification of 969 protein quantitative trait loci in an African American population with kidney disease attributed to hypertension
2022, Kidney InternationalCitation Excerpt :For example, the SNP rs704 in VTN was our most common trans-pQTL, similar to that seen in prior publications, and the vitronectin protein is believed to be a fundamental organizer of the extracellular environment.4,6,37 VTN is a member of the hemopexin family and an extracellular matrix protein known to interact with many receptors, including the integrins.38 Primarily synthesized in the liver, it is thought to be upregulated as part of the proinflammatory response and has been found in immune complex deposits in kidney fibrosis.37,39
The interplay of fibroblasts, the extracellular matrix, and inflammation in scar formation
2022, Journal of Biological Chemistry