Evolution of a regulatory gene family: HOM/HOX genes
References (67)
- et al.
The Structure of the Homeodomain and Its Functional Implications
Trends Genet
(1990) - et al.
What Determines the Specificity of Action of Drosophila Homeodomain Proteins?
Cell
(1990) - et al.
Homeodomain Proteins and the Regulation of Gene Expression
Curr Opin Cell Biol
(1990) - et al.
Homeobox Genes and Axial Patterning
Cell
(1992) - et al.
Early Evolutionary Origin of Major Homeodomain Sequence Classes
Genomics
(1993) Hox and HOM: Homologous Gene Clusters in Insects and Vertebrates
Cell
(1989)- et al.
The Murine and Drosophila Homeobox Gene Complexes Have Common Features of Organization and Expression
Cell
(1989) - et al.
Disruption of the Hox-1.6 Homeobox Gene Results in Defects in a Region Corresponding to Its Rostral Domain of Expression
Cell
(1991) - et al.
Homeosis in the Mouse Induced by a Null Mutation in the Hox-3.1 Gene
Cell
(1992) - et al.
The Abdominal Region of the Bithorax Complex
Cell
(1985)
A Homologous Protein-Coding Sequence in Drosophila Homeotic Genes and Its Conservation in Other Metazoans
Cell
Homcotic Genes of the Antennapedia Complex (ANTC) and Their Molecular Variability in the Phylogeny of the Drosophilididae
Isolation and Embryonic Expression of an Abdominal-A-Like Gene from the Lepidopteran, Manduca sexta
Development
Homeobox-Containing Genes in the Newt Are Organized in Clusters Similar to Other Vertebrates
Gene
PAUP Version 3.0.
Illinois Natural History Survey y
Expansion of the Hox Gene Family and the Evolution of Chordates
A Conserved DNA Sequence in Homeotic Genes of the Drosophila Antennapedia and Bithorax Complexes
Nature
Structural Relationships Among Genes that Control Development: Sequence Homology between the Antennnapedia, Ultrabithorax and fusbi tarazu loci of Drosphila
The Homeodomain: A New Face for the Helix-Turn-Helix?
Bioessays
Homeobox Genes in Mouse Development
The Structure and Function of the Homeodomain
Biochim Biophys Acta
The Structural and Functional Organization of the Murine HOX Gene Family Resembles that of Drosophila Homeotic Genes
EMBO J
Regionally Restricted Developmental Defects Resulting from Targeted Disruption of the Mouse Homeobox Gene Hox-1.5
Nature
Developmental Defects in the Ear, Cranial Nerves and Hindbrain Resulting from Targeted Disruption of the Mouse Homeobox Gene Hox-1.6
Nature
Hoxb-4 (Hox-2.6) Mutant Mice Show Homeotic Transformation of a Cervical Vertebra and Defects in the Closure of the Sternal
Cell
Genomics and Evolution of Murine Homeobox Genes
Molecular and Genetic Organization of the Antennapedia Gene Complex of Drosophila melanogaster
Adv Genet
A Homeotic Gene Cluster in the Red Flour Beetle
Nature
Nematode Homeobox Cluster
Nature
A Cluster of Antennapedia-Class Homeobox Genes in a Nonsegmented Animal
Science
Structural Changes in the Antennapedia Complex of Drosophila pseudoobscura
Genetics
Molecular Analysis of the Deletion Mutants in the E Homcotic Complex of the Silkworm Bombyx mori
Development
Identification of the Abdominal-A Homologue from Aedes aegypti and Structural Comparisons among Related Genes
Nucleic Acids Res
Cited by (66)
Duplications of hox gene clusters and the emergence of vertebrates
2013, Developmental BiologyCitation Excerpt :We experimentally challenged this view by using combined cluster deletions in mice, thus trying to produce animals carrying a more ‘ancestral’ complement of Hox genes. We initially focused on the HoxA and HoxB ‘sister’ clusters, which were proposed to derive from a late duplication event (Kappen and Ruddle, 1993; Amores et al., 1998; Ravi et al., 2009). The deletion of the complete HoxA cluster is embryonic lethal after 11–12.5 days of gestation (E11.0–E12.5) due to placental insufficiency and premature stenosis of the umbilical artery (Fig. S1a and b; see (Warot et al., 1997; Shaut et al., 2008; Scotti and Kmita, 2012)).
Identification of leech embryonic neurons that express a Hox gene required for the differentiation of a paired, segment-specific motor neuron
2013, International Journal of Developmental NeuroscienceCitation Excerpt :Proteins encoded by Hox genes are one such family of transcription factors. The transcription factors encoded by Hox/HOM genes are highly conserved in a number of different phyla (Kappen and Ruddle, 1993; Krumlauf, 1994). Hox gene expression in the early embryo follows a rule of colinearity that is related to the specification of anterior–posterior (A–P) regionalization: The expression of Hox genes located at the 3′ end of the Hox complex is located more anteriorly and occurs earlier in development than the expression of Hox genes at the 5′ end (Duboule and Morata, 1994; Frobius et al., 2008; Maconochie et al., 1996; Manak and Scott, 1994; Olson, 2008).
Organization and structure of hox gene loci in medaka genome and comparison with those of pufferfish and zebrafish genomes
2006, GeneCitation Excerpt :It may also valid that the primordial Hox cluster was multiplied by two rounds of duplication probably by polyploidization (Ohno, 1970). The topology in the phylogenical tree would be [(AB)(CD)] (Kappen and Ruddle, 1993; Zhang and Nei, 1996). Amores et al. (1998) initially proposed that in the presumed animal having two Hox clusters, group 12 gene was lost from one cluster (ancestor of A and B) and groups 2 and 7 genes were lost from the other cluster (ancestor of C and D).
Bioinformatic principles underlying the information content of transcription factor binding sites
2003, Journal of Theoretical BiologyThe homeodomain: An ancient evolutionary motif in animals and plants
2000, Computers and Chemistry