The Journal of Steroid Biochemistry and Molecular Biology
Enzymes of steroid metabolism in liver and other organsExtraglandular hormonal steroidogenesis in aged rats
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Cited by (26)
Gut feelings about bacterial steroid-17,20-desmolase
2021, Molecular and Cellular EndocrinologyCitation Excerpt :Evidence in the 1990's began to accumulate that the intestines, and IECs in the crypts, are sites of steroidogenesis aimed at regulating immune responses at the intestinal barrier. It was demonstrated that both the duodenum and colon expressed P450C17 mRNA and were capable of converting [4–14C] pregnenolone to dehydroepiandrosterone (DHEA) ex vivo, indicating the expression of CYP17 in the intestine (Dalla Valle et al., 1992, 1995; Bouguen et al., 2015). The expression of CYP11A1, CYP17 and CYP11B1 as well as cortisol biosynthesis was observed in human colorectal cell lines (Caco-2 & HT-29) as well as primary human intestinal cell lines and colorectal tumor tissue (Bouguen et al., 2015; Sidler et al., 2011).
Impairment of renal steroidogenesis at the onset of diabetes
2021, Molecular and Cellular EndocrinologyCitation Excerpt :In this work, we demonstrated that STZ treatment reduces steroidogenic proteins expression and pregnenolone synthesis to a greater extent precisely in the medulla, suggesting that diabetes might impair nephrosteroids-dependent mechanisms. Pregnenolone may be converted to dehydroepiandrosterone by CYP17A1 (Cytochrome P450c17), to pregnenolone sulfate by steroid sulfotransferase and to progesterone by 3β-hydroxysteroid dehydrogenase (3β-HSD) in rat kidney tissue (Dalla Valle et al., 1992, 2004; Kohjitani et al., 2006). Some indirect evidence may lead to hypothesize that the decrease in pregnenolone would be harmful to the kidney.
Neurosteroids and neuropathic pain management: Basic evidence and therapeutic perspectives
2019, Frontiers in NeuroendocrinologyCitation Excerpt :Therefore, to contribute to this objective requiring important global efforts, the present paper has critically reviewed and discussed basic, preclinical and translational evidence suggesting that neurosteroids may represent a relevant tool to exploit for the development of effective treatments against neuropathic pain. For several years, the production of endogenous steroids was exclusively ascribed to the adrenals and gonads but it is now well established that various other tissues such as the bowel, liver, prostate and nervous system may synthesize or metabolize steroids (Baulieu et al., 1999; Belanger et al., 1989; Dalla-Valle et al., 1992; Martel et al., 1994). The chemical nature of steroids allows them to behave as lipophilic molecules, particularly when they are free or non-conjugated to sulfate radicals.
Intestinal steroidogenesis
2015, SteroidsCitation Excerpt :The steroidogenic ability of the gut was first suggested in the beginning of the 90’s after looking for the expression and activity of the CYP17 (P450c17) enzyme along the gastrointestinal tract of adult rats (see Fig. 1 for a schematic representation of the cortisol and sex steroids synthesis pathway). When Dalla Valle et al. assessed the ex vivo metabolism of [4–14C]pregnenolone in various organs, they found that the duodenum and the colon were able to produce high amounts of dehydroepiandrosterone (DHEA), attesting the presence of 17α-hydroxylase and C 17,20-lyase activities in the intestine [21,22]. While rodents are corticosterone-secreting animals, due to the lack of expression of CYP17 in the adrenal, CYP17 expression in peripheral tissues (notably in the intestine) could lead to the synthesis of local cortisol in rats or mice.
Evidence for a key role of steroids in the modulation of pain
2009, PsychoneuroendocrinologyCitation Excerpt :Estrogens are C18 steroids having the estrane nucleus with a phenolic function at C3 (the first ring A being aromatic) and always an oxygenated function at C17; there is no methyl group at C10 (Fig. 1D). For several years, the production of endogenous steroids was exclusively ascribed to the adrenals and gonads but it is now well established that various other tissues such as the bowel, liver, prostate and nervous system may synthesize or metabolize steroids (Belanger et al., 1989; Dalla-Valle et al., 1992; Martel et al., 1994; Baulieu et al., 1999). The chemical nature of steroids allows them to behave as lipophilic molecules, particularly when they are free or non-conjugated to sulfate radicals.
Expression of cytochrome P450c17 and other steroid-converting enzymes in the rat kidney throughout the life-span
2004, Journal of Steroid Biochemistry and Molecular Biology