Trends in Biochemical Sciences
ReviewMolecular flypaper and atherosclerosis: structure of the macrophage scavenger receptor
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Interactions of ferritin with scavenger receptor class A members
2020, Journal of Biological ChemistryCitation Excerpt :In addition, CD163, a scavenger receptor with several SRCR domains, does not show binding activities with ferritin, suggesting that the binding of ferritin may be limited to a specific set of SRCR domains, such as those in the SR-A family. A distinct feature of SR-A family members is that they form homotrimers on the cell surface (11, 12, 57–59). It has been shown that the trimeric form of SCARA1 increases its binding affinity with spectrin significantly (20).
Glycated Serum Albumin and AGE Receptors
2015, Advances in Clinical ChemistryCitation Excerpt :Only MSR1, but none of the other class A scavenger receptors, is known to bind AGE. MSR1 is primarily expressed on macrophages and has homeostatic function by clearing modified lipids and proteins [192,201]. Together with CD36, MSR1 is the major uptake receptor for acLDL and oxLDL in murine macrophages [202] and likely to be involved in atherogenesis [203].
Cell delivery of therapeutic nanoparticles
2011, Progress in Molecular Biology and Translational ScienceCitation Excerpt :The outer core imparts stability to the nanosuspension, determines particle circulation time, and defines the interaction of the nanoparticle with the surrounding environment and cell surfaces. Charged carriers are generally taken up rapidly by mononuclear phagocytes, immunocytes, and stem cells through interaction with plasma membrane receptors.245–251 These receptors include mannose receptor, complement and Fc receptors that recognize mannans and integrins, and complement and antibody opsonized particles.
Supramolecular assemblies for the active drug targeting to the brain
2009, Journal of Drug Delivery Science and TechnologyThe role of innate immunity in atherogenesis
2009, Journal of Lipid ResearchCitation Excerpt :Via their ability to sample their environment and present antigens to T- and B-cells, macrophages and dendritic cells serve as vital links between innate and adaptive immune responses. The first such receptor identified, the “acetyl LDL receptor,” now known as SR-A (37), which comes in several varieties, not only binds modified LDL, including OxLDL, but of relevance to our discussion, also binds both gram positive and gram negative microbial ligands, including live bacteria. Indeed, SR-A-deficient mice have enhanced susceptibility to certain infections, such as Listeria monocytogenes and Staphylococcus aureus (38).
High tissue factor-expressing human monocytes carry low surface CD36: Application to intersubject variability
2007, Journal of Thrombosis and Haemostasis