Trends in Biochemical Sciences
Volume 18, Issue 6, June 1993, Pages 215-220
Regulation of src family tyrosine kinases in lymphocytes
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Cited by (133)
The cytoplasmic tail of CD45 is released from activated phagocytes and can act as an inhibitory messenger for T cells
2008, BloodCitation Excerpt :CD45 is a prototypic transmembrane protein tyrosine phosphatase (PTP), and it is generally accepted today that it sets the threshold of positive and negative signaling events in leukocytes.12-15 Through dephosphorylation and activation of the src-family kinases Lck, Fyn, and Lyn, CD45 is a positive regulator for signaling via the T-cell and B-cell receptors, respectively.16-18 On the other hand, through dephosphorylation of JAK, CD45 has been shown to negatively regulate cytokine receptor signaling and promotes viral infections.19
A weak Lck tail bite is necessary for lck function in T cell antigen receptor signaling
2007, Journal of Biological ChemistryFeasibility study using surface-enhanced Raman spectroscopy for the quantitative detection of tyrosine and serine phosphorylation
2007, Biochimica et Biophysica Acta - General SubjectsLymphocyte-specific protein tyrosine kinase is a novel risk gene for Alzheimer disease
2005, Journal of the Neurological SciencesProtein tyrosine phosphatases in T cell physiology
2004, Molecular ImmunologyEffects of hemizygous CD45 expression in the autoimmune Fasl<sup>gld/gld</sup>syndrome
2001, Cellular Immunology
Copyright © 1993 Published by Elsevier Ltd.