Trends in Biochemical Sciences
Special issueSH2 and SH3 domains as molecular adhesives: the interactions of Crk and Abl
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2014, Journal of Biological ChemistryCitation Excerpt :This feature is commonly found in proteins that are targeted to lipid rafts (38). The intracellular sequence of chB6 contains conserved proline residues typical of SH3-domain binding sites that are found in signal-transducing receptors (39). Within the extracellular region, our analysis detected the presence of two immunoglobulin (Ig)-like domains (Fig. 6A).
The WH2 Domain and Actin Nucleation: Necessary but Insufficient
2016, Trends in Biochemical SciencesLeukemia-associated mutations in SHIP1 inhibit its enzymatic activity, interaction with the GM-CSF receptor and Grb2, and its ability to inactivate PI3K/AKT signaling
2012, Cellular SignallingCitation Excerpt :Of the other 12 mutants analyzed, mutant P1039S was also not able to reduce pAKT(S473) in Jurkat cells, even though this mutant showed a normal specific activity. Interestingly, the mutation P1039S is localized in a PXXP motif which is the consensus sequence for the binding of SH3 domains [41]. Therefore, we postulate that the P1039XXP motif in SHIP1 is part of a binding site for a protein with an SH3 domain.
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