Skeletal muscle endurance training improves peripheral oxidative capacity, exercise tolerance, and health-related quality of life in women with chronic congestive heart failure secondary to either ischemic cardiomyopathy or idiopathic dilated cardiomyopathy☆
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Sex-Based Differences in Heart Failure: JACC Focus Seminar 7/7
2022, Journal of the American College of CardiologyCitation Excerpt :In an individual-level meta-analysis of MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy), RAFT (Resynchronization–Defibrillation for Ambulatory Heart Failure Trial), and REVERSE (REsynchronization reVErses Remodeling in Systolic Left vEntricular Dysfunction) performed by the U.S. Food and Drug Administration (FDA), there was a 76% reduction in HF or death (HR: 0.24; 95% CI: 0.11-0.53) from CRT-D for women with no significant benefit in men at a QRS duration between 130 and 149 milliseconds; both women and men benefited from CRT-D with a QRS duration ≥150 milliseconds.49 Additional data are needed to support and validate sex-specific target dosing of pharmacological and device therapies, surgical revascularization with coronary artery bypass grafts, and implementation of tailored exercise training with cardiac rehabilitation.50,51 Contemporary clinical trial data addressing 3 emerging and established HF therapies—sodium-glucose co-transporter-2 inhibitor (SGLT2i), angiotensin receptor-neprilysin inhibitor (ARNI) (sacubitril/valsartan), and mineralocorticoid receptor antagonists (MRA)—additionally highlight the importance of sex-specific subgroup analyses.
Sedentary behavior & health-related quality of life among congestive heart failure patients
2016, International Journal of CardiologyPrognosis: Does exercise training reduce adverse events in heart failure?
2015, Heart Failure ClinicsEffect of endurance training on the determinants of peak exercise oxygen consumption in elderly patients with stable compensated heart failure and preserved ejection fraction
2012, Journal of the American College of Cardiology
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This study was supported by grants from the National Board of Health and Welfare, the Medical Research Council (No. 4494, 9515), and the Heart and Lung Foundation, Sweden.