A longitudinal study of human papillomavirus carriage in human immunodeficiency virus–infected and human immunodeficiency virus–uninfected women☆,☆☆,★
Section snippets
Material and methods
Between March 1990 and May 1994 268 human HIV-infected women and 265 HIV-uninfected women were entered into a longitudinal study. They were recruited from the State University Health Science Center at Brooklyn, Kings County Hospital Center, and health care settings in central Brooklyn, an urban, largely minority community. Inclusion criteria for the seropositive women were documented HIV infection without Centers for Disease Control and Prevention defined acquired immunodeficiency syndrome
Results
The prevalence at baseline of any HPV type, oncogenic or nononcogenic, was 73% and 43% among HIV seropositive and seronegative women, respectively (p < 0.0001). The prevalence of oncogenic types in the same groups was 32.5% and 17.0% (p < 0.001). To focus on the HPV types of most clinical importance, the following analyses are limited to oncogenic HPV. Among the HIV-infected and uninfected women, 151 and 261, respectively, had at least one follow-up during which they were tested for oncogenic
Comment
We have found, in a cohort of sexually active women in Brooklyn, that HIV-seropositive women are more likely to have a new oncogenic HPV detected during follow-up and to show persistent carriage of oncogenic HPV types. Because persistent carriage of HPV has previously been linked to chronic cervical dysplasia,8 these findings may have substantial clinical relevance.
Several of our findings are consistent with previous reports focusing on HPV infection among sexually active, presumably
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2016, Journal of InfectionCitation Excerpt :Participants with a confirmed positive HIV test after the enrollment visit were referred to care and remained on trial.9 However, HIV-positive women (n = 3) post-enrollment were removed from the current analysis as HIV is known to influence HPV natural history.10 At the enrollment and 7-month visits, sexual history, health, and sociodemographic characteristics were assessed by a tablet-based questionnaire using a computer-assisted self-interview available in English, Xhosa, and Afrikaans.
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2013, Journal of Clinical VirologyCitation Excerpt :Of the known oncogenic types, HPV types 16 and 18 are responsible for up to 70% of cancers [4–6]. HPV detection is considerably more common among women infected with the human immunodeficiency virus (HIV) compared to uninfected women [7–14]. Furthermore, women infected with HIV are known to be at increased risk of HPV-associated disease, including cervical intraepithelial neoplasia (CIN) [15,16].
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From the Departments of Obstetrics and Gynecology,a Preventive Medicine,b and Internal Medicinec of the State University Health Science Center at Brooklyn and the Departments of Pediatrics, Microbiology and Immunology, Epidemiology and Social Medicine,d Albert Einstein College of Medicine.
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Reprint requests: Howard Minkoff, MD, Maimonides Medical Center, 967 48th St., Brooklyn, NY 11219.
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