Biochemical and Biophysical Research Communications
Formaldehyde treated albumin contains monomeric and polymeric forms that are differently cleared by endothelial and kupffer cells of the liver: Evidence for scavenger receptor heterogeneity
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Geometry and surface characteristics of gold nanoparticles influence their biodistribution and uptake by macrophages
2011, European Journal of Pharmaceutics and BiopharmaceuticsCitation Excerpt :The reduced uptake of spherical particles in the presence of serum suggests that their uptake is opsonin-independent and is probably through direct recognition by scavenger receptors. It is known that scavenger receptors recognize anionic particles and facilitate uptake by the RES [50–52]. Negatively charged spherical particles can potentially bind to available cationic sites on the macrophage surface and be recognized by scavenger receptors while adsorption of proteins on their surface may alter their overall charge, prevent such interaction and result in fewer uptake.
A novel lipid-based drug carrier targeted to the non-parenchymal cells, including hepatic stellate cells, in the fibrotic livers of bile duct ligated rats
2007, Biochimica et Biophysica Acta - BiomembranesCitation Excerpt :The polyanionic character of the molecule may classify it as a ligand for ScR class A. We hypothesised that accumulation of M6P-HSA liposomes in LEC and KC may be mediated through ScR class A, since they do not express significant levels of M6P/IGF II receptor [18,30] but are known to express different types of ScR, including ScR class A [31]. To examine this, 5 min prior to injection of M6P-HSA liposomes, poly I, which is a competitive inhibitor of ScR class A [32] was injected into BDL-3 rats.
Pharmacokinetics of a hepatic stellate cell-targeted doxorubicin construct in bile duct-ligated rats
2007, Biochemical PharmacologyCitation Excerpt :The main novelty of the present study therefore is that it also describes the time-course of this hepatic uptake, which revealed that major hepatic uptake already takes place within the first minutes after injection and plateau levels are reached within 5 min. It should be realized however that many modified proteins are taken-up by the liver, by virtue of scavenger receptor-mediated clearance by the mononuclear phagocyte system [22,23]. Indeed, as also the case for tumour-targeted proteins, intrahepatic uptake of M6PHSA-DOX by macrophages and endothelial cells was observed.
Fetuin mediates hepatic uptake of negatively charged nanoparticles via scavenger receptor
2007, International Journal of PharmaceuticsHepatic uptake of negatively charged particles in rats: Possible involvement of serum proteins in recognition by scavenger receptor
2004, Journal of Controlled ReleaseCitation Excerpt :In the past 20 years, scavenger receptors are found not only to be able to recognize endogenous molecules such as collagen [9] and altered-self such as apoptotic cells [10], but also to bind, internalize and degrade exogenous pathogen such as bacteria [11]. In addition, it was also reported that these receptors play a very important role to remove a variety of negatively charged substances such as dextran sulfate [12], formaldehyde-treated albumin [13] and liposomes containing negatively charged phospholipids [14]. On the other hand, our previous study showed that the surface hydrophobicity of polystyrene nanospheres with the size of 50 nm (NS-50) largely changes by the association of serum proteins on the particle surface [4].