The effect of inosine on the post ischemic heart as bio-energy recovering factor in 31P-MRS

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Perfused guinea-pig hearts, which were analyzed by 31P-MRS, were subjected to 30 and 60 minute ischemia and reperfused using two perfusates, one containing 200μ M inosine, and the other without inosine. After 4 hour reperfusion with inosine, ATP levels increased to 95.5 % of preischemic value (30 minute ischemia) and 76.2 % (60 minute ischemia). However, after 4 hour reperfusion without inosine, ATP levels increased only to 72.2 % (30 minute ischemia) and to 48.2 % (60 minute ischemia). In 60 minute ischemic hearts reperfused with inosine, left ventricular maximal positive dp/dt (LV dp/dt) was improved significantly to 82.4 % after 6 hour reperfusion in contrast to hearts reperfused without inosine (43.1 %). Administration of inosine was very useful for increasing myocardial gross energy product and improving cardiac performance.

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